Published Online
on November 6, 2003

A more recent version of this article appeared on December 1, 2003

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Submitted on June 26, 2003
Accepted on July 22, 2003

Endovascular Treatment of Intracranial Aneurysms With Radioactive Coils. Initial Clinical Experience

Jean Raymond MD^*; Daniel Roy MD; Philippe Leblanc PhD; Sjoerd Roorda PhD; Christian Janicki PhD; Lysanne Normandeau BSc; François Morel; Guylaine Gevry BSc; Jean-Paul Bahary MD; Miguel Chagnon PhD; François Guilbert MD; and Alain Weill MD

From the Departments of Radiology (J.R., D.R., F.G., A.W.), Radio-Oncology (J-P.B.), Physics and Biomedical Engineering (L.N.), and Research Center (J.R., P.L., F.M., G.G.), Centre hospitalier de l’Université de Montréal (CHUM)-Notre Dame Hospital; Departments of Physics (S.R.) and Mathematics and Statistics (M.C.), University of Montreal; and Department of Medical Physics, McGill University Health Centre (C.J.), Montreal, Quebec, Canada.

^* To whom correspondence should be addressed. E-mail: dr_jean_raymond{at}hotmail.com.

Background and Purpose--Endovascular treatment of intracranial aneurysms is safe and effective but is associated with angiographic recurrences. Beta radiation prevents recanalization after coil embolization in experimental models. We wanted to assess the feasibility of using radioactive coil embolization to improve long-term results of endovascular treatment.

Methods--Platinum coils were ion-implanted with 0.13 to 0.26 µCi/cm of ³²P. Forty-one patients aged 34 to 84 years with 44 aneurysms with a high propensity for recurrences were included. Radioactive coils were introduced into aneurysms to reach a target volumetric activity of 0.018 µCi/mm³. Nonradioactive coils were also used to ensure the same safety and the same angiographic results as the standard procedure. Angiographic results, procedure-related complications, and neurological events during follow-up were recorded. Angiographic follow-up data are available in 36 lesions 6 months after treatment.

Results--Forty of 44 aneurysms (91%) could be treated with radioactive coils. Target activities could be reached in 88% of lesions that could actually be coiled (35/40). Total activities ranged from 1.72 to 80.9 µCi, for a mean of 20.13±20.80 µCi. Procedure-related complications occurred in 7% of patients. Initial angiographic results were satisfactory (complete occlusions or residual necks) in 75% of lesions. Angiographic recurrences occurred in 11 (31%) of patients followed, within the expected range for standard coils. There was no complication from beta radiation during a mean follow-up period of 10 months.

Conclusions--Radioactive coil embolization is feasible; target volumetric activities can be reached in most aneurysms considered for endovascular treatment.

Key words: cerebral aneurysm • cerebrovascular disorders • endovascular therapy • radiation

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