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on December 1, 2003

A more recent version of this article appeared on December 1, 2003

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Submitted on June 10, 2003
Accepted on July 30, 2003

Anti--Fodrin Autoantibodies in Moyamoya Disease

Kouichi Ogawa MD; Shinji Nagahiro MD; Rieko Arakaki PhD; Naozumi Ishimaru DDS, PhD; Masaru Kobayashi MD; and Yoshio Hayashi DDS, PhD^*

From the Department of Pathology (R. A., N. I., M. K., Y. H.), Tokushima University School of Dentistry, and Department of Neurosurgery (K. O., S. N.), University of Tokushima School of Medicine, Tokushima, Japan.

^* To whom correspondence should be addressed. E-mail: hayashi{at}dent.tokushima-u.ac.jp.

Background and Purpose--Moyamoya disease (MMD) is a rare entity that results in progressive occlusion of the arteries of the circle of Willis, but the pathogenesis of MMD is unknown.

Methods--MMD sera (n=32) were tested for anti-endothelial cell antibodies by enzyme-linked immunoassays and flow cytometric analysis. Apoptosis was induced in human umbilical vein endothelial cells by tumor necrosis factor-.

Results--We found that a high proportion of MMD sera had anti-endothelial cell antibodies with apoptotic stimuli. Prominent reactivities of MMD sera (72%) with recombinant human -fodrin were observed.

Conclusions--Our study demonstrates that MMD sera contain a high incidence of anti--fodrin autoantibodies, providing new insight into the mechanisms of occlusion of MMD arteries.

Key words: -fodrin • autoantibodies • moyamoya disease

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