Published Online
on February 19, 2004

A more recent version of this article appeared on March 1, 2004

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Submitted on September 19, 2003
Accepted on November 11, 2003

Association of Mean Platelet Volume With Risk of Stroke Among 3134 Individuals With History of Cerebrovascular Disease

Philip Bath MD, FRCP^*; Charles Algert MPH; Neil Chapman MRCP; Bruce Neal MRCP(UK), PhD; and for the PROGRESS Collaborative Group

From the Institute of Neuroscience, University of Nottingham, Nottingham, UK (P.B.), and Institute for International Health, University of Sydney, Sydney, Australia (C.A., N.C., B.N.).

^* To whom correspondence should be addressed. E-mail: philip.bath{at}nottingham.ac.uk.

Background and Purpose--Mean platelet volume (MPV) is positively associated with measures of platelet activity and may be a useful indicator of the risk of vascular events in a variety of patient groups.

Methods--The association of MPV with the risk of stroke was assessed in the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). All participants had a history of cerebrovascular disease at baseline, and analyses were adjusted for the effects of potential confounders.

Results--The study followed 3134 individuals for an average of 3.9 years (mean age, 65 years; 71% male; average MPV, 10.0 fL). Three hundred eighty-three individuals had 402 stroke events, and 160 had major coronary events. MPV was positively associated with the risk of stroke, with an 11% increased relative risk (95% CI, 3% to 19%) of stroke per femtoliter greater MPV. There was no clear association of MPV with the risk of major coronary events (9% decreased relative risk; 95% CI, -23% to 7%). Perindopril did not alter MPV.

Conclusions--MPV is an independent predictor of the risk of stroke among individuals with a history of stroke or transient ischemic attack. The measurement of MPV may add useful prognostic information for clinicians managing patients with a history of cerebrovascular disease.

Key words: myocardial infarction • platelets • stroke, hemorrhagic • stroke, ischemic

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