Published Online
on February 12, 2004

A more recent version of this article appeared on March 1, 2004

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Submitted on October 20, 2003
Accepted on November 21, 2003

Evolution of Diaschisis in a Focal Stroke Model

S. Thomas Carmichael MD, PhD^*; Keith Tatsukawa BS; Diana Katsman BS; Naohiro Tsuyuguchi MD; and Harley I. Kornblum MD, PhD

From the Departments of Neurology (S.T.C., D.K.), Pediatrics, and Pharmacology and the University of California at Los Angeles Department of Energy Center for Molecular Medicine (K.T., N.T., H.I.K.), David Geffen School of Medicine at University of California at Los Angeles.

^* To whom correspondence should be addressed. E-mail: scarmichael{at}mednet.ucla.edu.

Background and Purpose--Stroke produces diaschisis in adjacent and connected regions. The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined.

Methods--Small cortical strokes were produced in the barrel cortex of rats. Relative glucose metabolism was determined in vivo over time with [¹⁸F]fluorodeoxyglucose small-animal positron emission tomography. Cerebral blood flow was measured with [¹⁴C]iodoantipyrine. Regions of hypometabolism and hypoperfusion were compared with histological damage in the same animals.

Results--Small cortical strokes produce an initial network of hypometabolism in a broad region of cortex adjacent to the stroke and in the striatum and thalamus on day 1. Cerebral blood flow is diminished only immediately around the cortical infarct on day 1. A substantial area of cortex adjacent to the stroke remains hypometabolic on day 8. This persistent cortical hypometabolism occupies the somatosensory cortex, forelimb motor cortex, and second somatosensory area.

Conclusions--Focal stroke produces ipsilateral diaschisis in connected cortical regions that is clearly distant from subtotal damage and may play a role in poststroke neuroplasticity.

Key words: cerebral cortex • neuronal plasticity • somatosensory cortex • tomography, emission computed

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