on March 4, 2004
Published online before print March 4, 2004, doi: 10.1161/01.STR.0000121646.23955.0f
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Submitted on September 23, 2003
From the Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK. * To whom correspondence should be addressed. E-mail: peter.rothwell{at}clneuro.ox.ac.uk.
Background--Appropriate design of molecular genetic studies of ischemic stroke requires an understanding of the genetic epidemiology of stroke. However, there are no published population-based data on heritability of aetiological subtypes of ischemic stroke, confounding by heritability of other vascular risk factors, or the relationship between heritability and age of onset. Methods--We studied family history of stroke (FHxStroke) and of myocardial infarction (FHxMI) in first-degree relatives in 2 population-based studies (Oxford Vascular Study [OXVASC]; Oxfordshire Community Stroke Project [OCSP]). We related FHxStroke and FHxMI to subtype of ischemic stroke, age, and the presence of vascular risk factors and performed a systematic review of all studies of FHxStroke by stroke subtype. Results--In our population-based studies and in 3 hospital-based studies, FHxStroke was least frequent in cardioembolic stroke (OR=0.74, 95%CI=0.58 to 0.95, P=0.02) but was equally frequent in the other subtypes. In OXVASC and OCSP, FHxStroke (P=0.02), FHxMI (P=0.04), and FHx of either (P=0.006) were associated with stroke at a younger age. Only FHxStroke was associated with previous hypertension (OR=1.59, 95%CI=1.08 to 2.35, P=0.02). FHxMI was more frequent in large-artery stroke (OR=1.63, 95%CI=0.99 to 2.69, P=0.05). Conclusion--Consistent results in our population-based studies and previous hospital-based studies suggest that inclusion bias is not a major problem for studies of the genetic epidemiology of stroke. Molecular genetic studies might be best targeted at non-cardioembolic stroke and younger patients. However, genetic susceptibility to hypertension may account for a significant proportion of the heritability of ischemic stroke.
Accepted on January 5, 2004
Heritability of Ischemic Stroke in Relation to Age, Vascular Risk Factors, and Subtypes of Incident Stroke in Population-Based Studies
U.G.R. Schulz MRCP, MD;
Key words: ischemia • stroke • history • risk factors
Related Article:
Stroke 2004 35: 824-825.
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