Published Online
on April 8, 2004

A more recent version of this article appeared on May 1, 2004

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Submitted on November 27, 2003
Accepted on January 21, 2004

Race-Specific Relationships Between Coronary and Carotid Artery Calcification and Carotid Intimal Medial Thickness

Lynne E. Wagenknecht DrPH^*; Carl D. Langefeld PhD; J. Jeffrey Carr MD; Ward Riley PhD; Barry I. Freedman MD; Shahriar Moossavi MD; and Donald W. Bowden PhD

From Departments of Public Health Sciences (L.E.W., C.D.L., J.J.C.), Radiology (J.J.C.), Neurology (W.R.), Internal Medicine (B.I.F., S.M.), and Biochemistry (D.W.B.), Wake Forest University School of Medicine, Winston-Salem, NC.

^* To whom correspondence should be addressed. E-mail: lwgnkcht{at}wfubmc.edu.

Background and Purpose--Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT).

Methods--Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants.

Results--Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes.

Conclusions--Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.

Key words: epidemiology • ethnicity • coronary calcification • carotid intimal medial thickness • atherosclerosis

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