Published Online
on April 29, 2004

A more recent version of this article appeared on June 1, 2004

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Submitted on January 7, 2004
Revised on February 13, 2004
Accepted on March 2, 2004

Aortic Arch Atherosclerotic Lesions and the Recurrence of Ischemic Stroke

Shigeru Fujimoto MD; Masahiro Yasaka MD^*; Ryoichi Otsubo MD; Hiroshi Oe MD; Kazuyuki Nagatsuka MD; and Kazuo Minematsu MD

From the Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, Osaka, Japan.

^* To whom correspondence should be addressed. E-mail: yasakam{at}hsp.ncvc.go.jp.

Background and Purpose--Aortic arch atherosclerotic lesions are often associated with embolic brain infarction. We investigated the relationship between stroke recurrence and the characteristics of aortic arch atherosclerotic lesions.

Methods--Among 487 stroke patients who underwent transesophageal echocardiography, 283 patients with brain embolism diagnosed without significant occlusive lesions (50%) in their cerebral arteries were included in this study. We measured the intima-media thickness (IMT) and evaluated the extension and mobility of the aortic arch atherosclerotic lesions. During a mean follow-up period of 3.4 years, we investigated the relationship between stroke recurrence and the various characteristics of the aortic arch atherosclerotic lesions.

Results--An IMT 4.0 mm was found in 67 patients (25.3%). In 51 of these patients, the aortic lesions extended to the origin of the branches of the arch. Recurrences of cerebral ischemic events were found in 32 patients (recurrence group) and not in the other 251 (nonrecurrence group). Aortic atheroma 4.0 mm (41% versus 22%), aortic atheroma extending to the branches (63% versus 39%), and both (38% versus 16%) were more frequently seen in the recurrence group than in the nonrecurrence group (P<0.05, P<0.1, P<0.01, respectively). After adjustment for age and the presence of hypertension, an aortic atheroma that was 4.0 mm as well as extending to the branches was found to be an independent predictor of ischemic stroke recurrence (hazard ratio=2.42, P<0.05).

Conclusions--Stroke recurrence is associated with the severity of the atheroma (IMT 4.0 mm) and plaque extension to the branches.

Key words: aorta • stroke • recurrence • echocardiography

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