on May 27, 2004
Published online before print May 27, 2004, doi: 10.1161/01.STR.0000131268.50418.b7
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Submitted on August 28, 2003
From the University Department of Radiology (R.A.T., J.-M.U., E.W., I.J., J.H.G.), Addenbrooke’s Hospital, Cambridge, UK; Department of Pathology (J.H., M.J.G.), Papworth Hospital, Cambridge, UK; GlaxoSmithKline (G.Q., L.W., J.B.), Translational Medicine and Technology, Addenbrooke’s Centre for Clinical Investigation, Addenbrooke’s Hospital, Cambridge, UK; Multi-Imaging Centre (J.N.S.), University Department of Anatomy, Cambridge, UK; and Academic Department of Neurosurgery (P.J.K.), Addenbrooke’s Hospital, Cambridge, UK. * To whom correspondence should be addressed. E-mail: jhg21{at}cam.ac.uk.
Background--It has been suggested that inflammatory cells within vulnerable plaques may be visualized by superparamagnetic iron oxide particle-enhanced MRI. The purpose of this study was to determine the time course for macrophage visualization with in vivo contrast-enhanced MRI using an ultrasmall superparamagnetic iron oxide (USPIO) agent in symptomatic human carotid disease. Methods and Results--Eight patients scheduled for carotid endarterectomy underwent multisequence MRI of the carotid bifurcation before and 24, 36, 48, and 72 hours after Sinerem (2.6 mg/kg) infusion. USPIO particles accumulated in macrophages in 7 of 8 patients given Sinerem. Areas of signal intensity reduction, corresponding to USPIO/macrophage-positive histological sections, were visualized in all 7 of these patients, optimally between 24 and 36 hours, decreasing after 48 hours, but still evident up to 96 hours after infusion. Conclusions--USPIO-enhanced MRI of carotid atheroma can be used to identify macrophages in vivo. The temporal change in the resultant signal intensity reduction on MRI suggests an optimal time window for the detection of macrophages on postinfusion imaging.
Revised on January 26, 2004
Accepted on March 22, 2004
In Vivo Detection of Macrophages in Human Carotid Atheroma. Temporal Dependence of Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced MRI
Rikin A. Trivedi MRCS;
Key words: magnetic resonance imaging • carotid arteries • atherosclerosis • macrophages
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