on July 1, 2004
Published online before print July 1, 2004, doi: 10.1161/01.STR.0000135766.22285.dc
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Submitted on April 20, 2004
From the Department of Neurology (K.J., C.C.T.), St. Elisabeth Hospital Tilburg, the Netherlands; and the Departments of Hematology (R.F., P.G.d.G.) and Neurology (J.v.G.), University Medical Center Utrecht, the Netherlands; and the Department of Neurology (P.J.K.), Erasmus Medical Center Rotterdam, the Netherlands. * To whom correspondence should be addressed. E-mail: K.Jellema{at}elisabeth.nl.
Background and Purpose--The cause of spinal dural arteriovenous fistulas (SDAVF) is unknown. In intracranial dural arteriovenous fistulas, an association with factor V Leiden mutation has been found. Therefore, we studied the association between prothrombotic factors and SDAVF. Methods--Factor V Leiden mutation, factor II mutation, protein S, protein C, factor VIII, von Willebrand factor, antithrombin III, and lupus anticoagulant were determined by means of standard laboratory tests in 40 patients and 119 control subjects matched for sex and age. Results--Factor V Leiden mutation was not found in the patient group and was found twice in the control group. Factor II mutation was found in 1 patient and in none of the control subjects. There was no decreased activity of protein S, protein C, factor VIII, von Willebrand factor, or antithrombin III in patients in comparison with controls. Lupus anticoagulant was not found in the patient group and once in the control subjects. Conclusions--We conclude that it is unlikely that prothrombotic factors are involved in the pathogenesis of spinal dural arteriovenous fistulas, but subtle associations are not ruled out.
Revised on May 12, 2004
Accepted on May 18, 2004
Spinal Dural Arteriovenous Fistulas Are Not Associated With Prothrombotic Factors
K. Jellema MD*;
Key words: spinal cord • arteriovenous fistula • thrombophilia
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