on July 8, 2004
Published online before print July 8, 2004, doi: 10.1161/01.STR.0000136721.95301.8d
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 23, 2004
From the Departments of Pharmacology and INSERM EMI 0107 (D.C., P.B., B.L., S.L.), Hôpital Européen Georges Pompidou, Paris, France; and the Department of Neurology (D.C., E.T., J.-L.M.), Hôpital Saint-Anne, Paris, France. * To whom correspondence should be addressed. E-mail: stephane.laurent{at}egp.ap-hop-paris.fr.
Background and Purpose--The cause of spontaneous cervical artery dissection (sCAD) is largely unknown. An underlying connective tissue disorder has often been postulated, but arterial mechanical properties have rarely been studied. The study aim was to determine the elastic properties of a cervical artery, the common carotid artery, and a distal muscular artery, the radial artery in sCAD patients. Methods--We studied 32 patients with previous sCAD (median delay: 2.2 years) and 32 control subjects with similar age and blood pressure. Internal diameter, intima-media thickness, distensibility, and Young’s elastic modulus were determined at the site of the right and left common carotid arteries and the radial artery using noninvasive high-resolution echotracking systems. Results--In patients with previous sCAD, cross-sectional distensibility and compliance of the affected carotid artery did not differ from those of the contralateral carotid artery. Young’s elastic modulus (ie, the stiffness of the wall material) was 58% higher (0.44±0.32 versus 0.28±0.15 kPa•103, P<0.001) and circumferential wall stress was 14% higher (56±12 versus 49±12 kPa, P<0.001) in sCAD patients than in controls. The highest tertile of common carotid artery Young’s elastic modulus was associated with an 8-fold higher risk of sCAD. Aortic stiffness, assessed from the carotid-femoral pulse wave velocity, and radial artery parameters did not differ between sCAD and controls. Conclusions--Carotid arteries, but not aorta and radial artery, displayed abnormal elastic properties in sCAD patients. Higher stiffness of carotid wall material and circumferential wall stress could increase the risk of dissection in these patients.
Revised on May 21, 2004
Accepted on May 26, 2004
Increased Stiffness of the Carotid Wall Material in Patients With Spontaneous Cervical Artery Dissection
David Calvet MD;
Key words: cerebrovascular accident • carotid arteries • dissection • vertebral artery
This article has been cited by other articles:
 |
|
 |
|
  C. Baracchini, S. Tonello, R. Vitaliani, B. Giometto, G. Meneghetti, and E. Ballotta Vasomotion in Multiple Spontaneous Cervical Artery Dissections Stroke, April 1, 2008; 39(4): 1148 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dittrich, A. Heidbreder, D. Rohsbach, J. Schmalhorst, I. Nassenstein, D. Maintz, E. B. Ringelstein, D. G. Nabavi, and G. Kuhlenbaumer Connective tissue and vascular phenotype in patients with cervical artery dissection Neurology, June 12, 2007; 68(24): 2120 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Vanmolkot, L. M. Van Bortel, and J. N. de Hoon Altered arterial function in migraine of recent onset Neurology, May 8, 2007; 68(19): 1563 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Brandt and S. R. Levine Spontaneous cervical artery dissection: Is there a gender innuendo? Neurology, September 26, 2006; 67(6): 932 - 933. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Paini, P. Boutouyrie, D. Calvet, A.-I. Tropeano, B. Laloux, and S. Laurent Carotid and Aortic Stiffness: Determinants of Discrepancies Hypertension, March 1, 2006; 47(3): 371 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Rubinstein, S. M. Peerdeman, M. W. van Tulder, I. Riphagen, and S. Haldeman A Systematic Review of the Risk Factors for Cervical Artery Dissection Stroke, July 1, 2005; 36(7): 1575 - 1580. [Abstract] [Full Text] [PDF]
|
|