Published Online
on August 26, 2004

A more recent version of this article appeared on October 1, 2004

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Submitted on February 4, 2004
Revised on July 16, 2004
Accepted on July 22, 2004

Prediction of Stroke by Self-Measurement of Blood Pressure at Home Versus Casual Screening Blood Pressure Measurement in Relation to the Joint National Committee 7 Classification. The Ohasama Study

Kei Asayama MD; Takayoshi Ohkubo MD, PhD; Masahiro Kikuya MD, PhD; Hirohito Metoki MD; Haruhisa Hoshi MD, PhD; Junichiro Hashimoto MD, PhD; Kazuhito Totsune MD, PhD; Hiroshi Satoh MD, PhD; and Yutaka Imai MD, PhD^*

From the Departments of Clinical Pharmacology and Therapeutics (K.A., H.M., K.T., Y.I.) and Drug Development and Clinical Evaluation (T.O., M.K., J.H.), Environmental Health Sciences (H.S.), Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai; and Ohasama Hospital, Iwate (H.H.), Japan.

^* To whom correspondence should be addressed. E-mail: imai{at}tinet-i.ne.jp.

Background and Purpose--To compare the predictive power of self-measured home blood pressure (HBP) and casual blood pressure (CBP) for stroke risk in relation to the Joint National Committee 7 (JNC-7) classification.

Methods--HBP and CBP measurements were taken in 1702 subjects (40 years) without a history of stroke, who were followed up for an average of 11 years. Subjects were classified into 4 groups on the basis of either HBP or CBP, according to the JNC-7 criteria: group 1 (HBP <115/75 mm Hg; CBP <120/80 mm Hg); group 2 (115/75HBP<135/85 mm Hg; 120/80CBP<140/90 mm Hg); group 3 (135/85HBP<150/95 mm Hg; 140/90CBP<160/100 mm Hg); and group 4 (HBP150/95 mm Hg; CBP 160/100 mm Hg). Groups 2, 3, and 4 were further divided into 2 subgroups (a and b): those without and with cardiovascular disease risks, respectively. The risk of the first stroke in these groups was examined by the Cox hazards model adjusted for age and sex.

Results--The stroke risk in groups 3b and 4b (defined by HBP and CBP) was 2 to 5x higher than that in group 1 with significant differences. The risk in groups 2a, 3a, and even 4a was not significantly different from that in group 1 by the CBP-based classification, but the risk in group 4a was significantly higher than that in group 1 by the HBP-based classification, which also showed a stepwise increase in risk from groups 2a to 4a.

Conclusions--The JNC-7 classification had a stronger predictive power using HBP-based classification compared with CBP-based classification, suggesting the usefulness of HBP in the management of hypertension.

Key words: blood pressure • hypertension • prospective studies • stroke

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