Published Online
on September 16, 2004

A more recent version of this article appeared on November 1, 2004

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Atherosclerosis of Cerebral Arteries in Alzheimer Disease

Alex E. Roher MD, PhD^*; Chera Esh BS; Afroza Rahman PhD; Tyler A. Kokjohn PhD; and Thomas G. Beach MD, PhD

From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.

^* To whom correspondence should be addressed. E-mail: alex.roher{at}sunhealth.org.

Abstract--A growing body of evidence suggests that vascular disease underlies Alzheimer dementia. Atherosclerotic lesions in the circle of Willis and large leptomeningeal vessels were quantified and found to correlate with Alzheimer disease (AD) clinical diagnosis and neuropathology. We hypothesize that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions. Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia.

Key words: Alzheimer disease • atherosclerosis • cerebral ischemia • circle of Willis

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