Published Online
on September 30, 2004

A more recent version of this article appeared on November 1, 2004

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Submitted on June 2, 2004
Accepted on August 5, 2004

Recovery and Rehabilitation in Stroke. Stem Cells

Olle Lindvall MD, PhD^* and Zaal Kokaia PhD

From the Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center (O.L.), and the Laboratory of Neural Stem Cell Biology, Stem Cell Institute (Z.K.), University Hospital, Lund, Sweden; and the Lund Strategic Research Center for Stem Cell Biology and Cell Therapy (O.L., Z.K.), Lund, Sweden.

^* To whom correspondence should be addressed. E-mail: olle.lindvall{at}neurol.lu.se.

Abstract--The recent demostration that neurons for transplantation can be generated from stem cells and that the adult brain produces new neurons in response to stroke has raised hope for the development of a stem cell therapy for patients affected with this disorder. In this review we propose a road map to the clinic and describe the different scientific tasks that need to be accomplished to move stem cell-based approaches toward application in stroke patients.

Key words: acute care • rehabilitation • stem cells • stem cell transplantation

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