Published Online
on October 7, 2004

A more recent version of this article appeared on November 1, 2004

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Submitted on June 2, 2004
Accepted on August 24, 2004

Are There Genetic Influences on Sporadic Brain Arteriovenous Malformations?

William L. Young MD^* and Guo-Yuan Yang MD, PhD

From the Departments of Anesthesia and Perioperative Care (W.L.Y., G-Y.Y.), Center for Cerebrovascular Research (W.L.Y., G-Y.Y.), Neurological Surgery (W.L.Y., G-Y.Y.), and Neurology, University of California, San Francisco, Calif.

^* To whom correspondence should be addressed. E-mail: ccr{at}anesthesia.ucsf.edu.

Abstract--The genesis of brain arteriovenous malformations remains enigmatic. We reviewed some pathways involving inflammatory and angiogenic signals that are amenable to the study of genetic single-nucleotide polymorphisms associated with the sporadic disease. Such study can yield insights into arteriovenous malformation pathogenesis and suggest possible fruitful approaches to developing medical therapy. Moreover, single-nucleotide polymorphisms identification would provide targets for risk stratification for planning clinical trials and eventually guiding management.

Key words: acute care • arteriovenous malformations • intracranial hemorrhages • polymorphism, single nucleotide

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