Published Online
on February 3, 2005

A more recent version of this article appeared on March 1, 2005

This Article Full Text (PDF) All Versions of this Article: 36/3/676    most recent 01.STR.0000155743.60019.e5v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ko, N. U. Articles by Young, W. L. Search for Related Content PubMed PubMed Citation Articles by Ko, N. U. Articles by Young, W. L. Pubmed/NCBI databases Substance via MeSH Related Collections Other arteriosclerosis Computerized tomography and Magnetic Resonance Imaging Angioplasty and Stenting

Submitted on October 8, 2004
Accepted on October 8, 2004

Magnetic Resonance Perfusion Tracks ¹³³Xe Cerebral Blood Flow Changes After Carotid Stenting

Nerissa U. Ko MD; Achal S. Achrol BSc; Alastair J. Martin PhD; Manju Chopra MD; David A. Saloner PhD; Randall T. Higashida MD; and William L. Young MD^*

From the Departments of Neurology (N.U.K., W.L.Y.), Radiology (A.J.M., D.A.S., R.T.H.), Anesthesia and Perioperative Care (W.L.Y.), Neurological Surgery (R.T.H., W.L.Y.), and Center for Cerebrovascular Research (A.S.A., M.C., D.A.S., W.L.Y.), University of California, San Francisco; and Philips Medical Systems (A.J.M.), Cleveland, Ohio.

^* To whom correspondence should be addressed. E-mail: ccr{at}anesthesia.ucsf.edu.

Background and Purpose--To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial ¹³³Xe washout method.

Methods--Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial ¹³³Xe washout before and after carotid stenting. MR perfusion was compared with ¹³³Xe-CBF values using Pearson linear correlation analysis.

Results--We observed a mean 37±38% increase in ¹³³Xe-CBF and a mean 19±27% increase in relative CBF (rCBF) by MR perfusion immediately after stent placement. Relative (percent) changes in MR-rCBF showed a close and linear correlation to those seen in ¹³³Xe-CBF (r=0.91; R²=0.84; P=0.002). There was a trend for MR perfusion to underestimate change in CBF at higher relative changes in flow.

Conclusion--Bolus-tracking MR perfusion correlates with ¹³³Xe-CBF in estimating postprocedural increases in blood flow but may underestimate the magnitude of the change with higher relative changes.

Key words: cerebral blood flow • magnetic resonance imaging • xenon

This article has been cited by other articles:

				T.-Y. Chang, H.-L. Liu, T.-H. Lee, W.-C. Kuan, C.-H. Chang, H.-C. Wu, T.-C. Wu, and Y.-J. Chang Change in Cerebral Perfusion after Carotid Angioplasty with Stenting Is Related to Cerebral Vasoreactivity: A Study Using Dynamic Susceptibility-Weighted Contrast-Enhanced MR Imaging and Functional MR Imaging with a Breath-Holding Paradigm AJNR Am. J. Neuroradiol., August 1, 2009; 30(7): 1330 - 1336. [Abstract] [Full Text] [PDF]

				J-M Olivot, M. Mlynash, G. Zaharchuk, M. Straka, R. Bammer, N. Schwartz, M. G. Lansberg, M. E. Moseley, and G. W. Albers Perfusion MRI (Tmax and MTT) correlation with xenon CT cerebral blood flow in stroke patients Neurology, March 31, 2009; 72(13): 1140 - 1145. [Abstract] [Full Text] [PDF]

				S. Haller, L. H. Bonati, J. Rick, M. Klarhofer, O. Speck, P. A. Lyrer, D. Bilecen, S. T. Engelter, and S. G. Wetzel Reduced Cerebrovascular Reserve at CO2 BOLD MR Imaging Is Associated with Increased Risk of Periinterventional Ischemic Lesions during Carotid Endarterectomy or Stent Placement: Preliminary Results Radiology, October 1, 2008; 249(1): 251 - 258. [Abstract] [Full Text] [PDF]