on March 3, 2005
Published online before print March 3, 2005, doi: 10.1161/01.STR.0000160007.57787.4c
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Submitted on December 9, 2004
From the Department of Neurology (Y.S.K.), Wonkwang University, School of Medicine, Iksan, South Korea; Department of Neurology (Z.G., R.M., A.V.A.), University of Texas-Medical School at Houston; and Neurovascular Unit (C.A.M.), Vall d’Hebron Hospital, Barcelona, Spain. * To whom correspondence should be addressed. E-mail: avalexandrov{at}att.net.
Background--Patients with isolated middle cerebral artery (MCA) and tandem MCA/internal carotid artery (ICA) obstruction have similar presenting symptoms and stroke severity. We aimed to investigate early recanalization of MCA and clinical outcomes in patients with tandem ICA/MCA obstructions and isolated MCA occlusion. Methods--Patients with MCA occlusion on pretreatment transcranial Doppler were treated with intravenous tissue plasminogen activator. ICA lesions were detected with carotid duplex. Early neurological improvement (ENI) was defined by reduction of National Institutes of Health Stroke Scale (NIHSS) Results--Among 104 patients, 31% had tandem lesions and 69% had isolated MCA occlusions. Complete recanalization rate was 39% in isolated MCA occlusion group and 9% in tandem group (P=0.002). ENI at 24 hours occurred in 46% of the isolated MCA occlusion group and in 25% of the tandem group (P=0.045). Good outcome was achieved by 30% and 39% respective patients (NS). Conclusion--The tandem lesion group showed lower early recanalization rate and ENI rate than the isolated MCA occlusion group. Despite this, good outcomes were similar in both groups.
Revised on December 9, 2004
Accepted on December 24, 2004
Early Recanalization Rates and Clinical Outcomes in Patients With Tandem Internal Carotid Artery/Middle Cerebral Artery Occlusion and Isolated Middle Cerebral Artery Occlusion
Yo Sik Kim MD;
10 points or total NIHSS 
3 points. Good outcome at 3 months was a modified Rankin score of 2.
Key words: stroke, acute • outcome • ultrasonography, Doppler, transcranial • thrombolysis • middle cerebral artery occlusion
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