on May 12, 2005
Published online before print May 12, 2005, doi: 10.1161/01.STR.0000166057.96174.88
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Submitted on January 10, 2005
From the Departments of Neurology (C.B., S.S.) and Neuroradiology (P.S.), University of Heidelberg, Germany. * To whom correspondence should be addressed. E-mail: christian_berger{at}med.uni-heidelberg.de.
Background--Large areas of restricted diffusion in the middle cerebral artery (MCA) territory are highly predictive of severe and potentially space-occupying MCA stroke. A reduction of diffusion-weighted MRI (DWI) lesions occurs in 20% to 40% of acute stroke patients with early reperfusion. Methods--We report of a patient with a severe stroke syndrome who was treated with early moderate hypothermia but not thrombolysis. Results--The initially large DWI deficit of the whole MCA territory contrasted to the relatively small final lesion restricted to the basal ganglia on MRI and computed tomography scan. Conclusion--This case describes an unexpected reduction of a DWI lesion after early moderate hypothermia and spontaneous recanalization 3 days after stroke onset. We discuss potential reasons for the unexpected DWI lesion reduction.
Revised on February 8, 2005
Accepted on February 25, 2005
Reduction of Diffusion-Weighted MRI Lesion Volume After Early Moderate Hypothermia in Ischemic Stroke
Christian Berger MD*;
Key words: glutamates • magnetic resonance imaging • stroke • stroke, ischemic
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