on July 14, 2005
Published online before print July 14, 2005, doi: 10.1161/01.STR.0000174289.34110.b0
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Submitted on January 21, 2005
From the Vascular Research Laboratory (J.L.M.-V., L.M.B.-C., A.G.-H., B.M.-G., J.E.) and Department of Cardiology (J.T.), Fundación Jiménez Díaz, Autónoma University, Madrid, Spain; the Departments of Vascular Surgery (M.V., J.S.) and Pathology (L.O.), Hospital Clínico de San Carlos, Complutense University; and R&D Department (G.H.), Medical Division, Pfizer, Madrid, Spain. * To whom correspondence should be addressed. E-mail: jegido{at}fjd.es.
Background and Purpose--To investigate the effect of short-term high-dose atorvastatin on blood and plaque inflammation in patients with carotid stenosis. Methods--Twenty patients undergoing carotid endarterectomy without previous statin treatment were randomized to receive either atorvastatin 80 mg/d (n=11) or no statins (n=9) for 1 month. We studied inflammatory mediators in plasma (enzyme-linked immunosorbent assay), peripheral blood mononuclear cells (PBMCs; quantitative RT-PCR and EMSA) and plaques (immunohistochemistry and Southwestern histochemistry). Results--Atorvastatin significantly decreased total and low-density lipoprotein cholesterol and prostaglandin E2 plasma levels. PBMCs from treated patients showed impaired NF- Conclusions--Intensive treatment with atorvastatin decreases inflammatory activity of PBMCs and carotid atherosclerotic plaques in 1 month. These data strongly suggest that the antiinflammatory effect of high doses of statins in humans can be seen very early.
Revised on April 22, 2005
Accepted on May 12, 2005
Intensive Treatment With Atorvastatin Reduces Inflammation in Mononuclear Cells and Human Atherosclerotic Lesions in One Month
Jose Luis Martín-Ventura PhD;
B activation and MCP-1 and COX-2 mRNA expression. Carotid atherosclerotic plaques demonstrated a significant reduction in macrophage infiltration, activated NF-B, and COX-2 and MCP-1 expression.
Key words: atherosclerosis • blood • carotid arteries • inflammation
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