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Published Online
on August 4, 2005

Stroke. 2005
Published online before print August 4, 2005, doi: 10.1161/01.STR.0000177866.13451.e4
A more recent version of this article appeared on September 1, 2005
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Submitted on January 30, 2005
Revised on June 7, 2005
Accepted on June 14, 2005

Chagas Disease Is an Independent Risk Factor for Stroke. Baseline Characteristics of a Chagas Disease Cohort

Jamary Oliveira-Filho MD, PhD*; Leila C. Viana; Rodrigo M. Vieira-de-Melo; Frederico Faiçal MD; Jorge A. Torreão MD; Flávio A.G.A. Villar MD; and Francisco J.F.B. Reis MD

From the Cardiomyopathy Clinic, Hospital Universitário Professor Edgard Santos, Federal University of Bahia, Brazil.

* To whom correspondence should be addressed. E-mail: jamaryof{at}ufba.br.

Background and Purpose--Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic.

Method--We screened 305 consecutive cardiopathy patients. Significant predictors of stroke in univariable analyses were included in a multivariable model.

Results--Stroke was more frequent in CD (15.0%) compared with other cardiopathies (6.3%; P=0.015). Other predictors of stroke in univariable analyses were previous diabetes or cardioversion and use of amiodarone, antiplatelet agents, and warfarin. In multivariable analysis, remaining predictors of stroke were CD (odds ratio [OR], 1.09; 95% CI, 1.02 to 1.17), cardioversion (OR, 1.07; 95% CI, 1.02 to 1.13), and diabetes (OR, 1.12; 95% CI, 1.01 to 1.24).

Conclusions--In conclusion, CD is a risk factor for stroke, independent of systolic dysfunction or presence of cardiac arrhythmias.


Key words: cerebrovascular disorders • stroke • trypanosomiasis




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L. C. Paixao, A. L. Ribeiro, R. A. Valacio, and A. L. Teixeira
Chagas Disease: Independent Risk Factor for Stroke
Stroke, December 1, 2009; 40(12): 3691 - 3694.
[Abstract] [Full Text] [PDF]