Published Online
on August 18, 2005

A more recent version of this article appeared on September 1, 2005

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Submitted on February 5, 2005
Revised on April 13, 2005
Accepted on April 21, 2005

Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke

Stamatis P. Efstathiou MD^*; Dimitrios I. Tsioulos MD; Aphrodite G. Tsiakou MD; Yannis E. Gratsias MSc, BSc; Angelos V. Pefanis MD; and Theodore D. Mountokalakis MD

From the Center for the Prevention of Cardiovascular Disease (S.P.E., Y.E.G., T.D.M.), "Hygieias Melathron," Athens, Greece; Internal Medicine Department (D.I.T.), Metropolitan Hospital, Pireus, Greece; and Third University Department of Medicine (A.G.T., A.V.P.), Medical School, Sotiria General Hospital, Athens, Greece.

^* To whom correspondence should be addressed. E-mail: sefstath{at}tellas.gr.

Background and Purpose--This study aimed to investigate the association between plasma adiponectin levels and 5-year survival after first-ever ischemic stroke.

Methods--Plasma adiponectin measured within 24 hours after first-ever ischemic stroke was related to 5-year outcome. The Kaplan-Meier technique was applied in survival analysis, and the Cox proportional hazards model was used to evaluate the relationship between risk factors and prognosis.

Results--The probabilities of death were 92.8%, 52.5%, and 10.5% (P<0.001) for patients stratified according to tertiles of adiponectin (<4 µg/mL, 4 to 7 µg/mL, and >7 µg/mL, respectively). The relative risk of death was 8.1 (95% CI, 3.1, 24.5; P<0.001) for individuals with adiponectin levels in the lowest tertile compared with the upper tertile. Adiponectin <4 µg/mL (hazard ratio [HR], 5.2; 95% CI, 2.1, 18.4; P<0.001), score >15 in the National Institutes of Health Stroke Scale (HR, 3.6; 95% CI, 1.7, 15.9; P<0.001), and coronary heart disease (HR, 2.9; 95% CI, 1.5, 12.3; P<0.001) were independently associated with mortality.

Conclusions--Low plasma adiponectin is related to an increased risk of 5-year mortality after first-ever ischemic stroke, independently of other adverse predictors.

Key words: inflammation • risk factors

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Adiponectin: Spectator or Player?

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