on August 18, 2005
Published online before print August 18, 2005, doi: 10.1161/01.STR.0000177881.34840.cf
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Submitted on April 22, 2005
From the Department of Neurology, the Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia DF Brazil. * To whom correspondence should be addressed. E-mail: javier{at}bsb.sarah.br.
Background and Purpose--We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients. Method--A total of 130 consecutive young and 200 elderly stroke patients were studied. Results--Prevalence of thrombophilia was, respectively: protein S deficiency (11.5% versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (1.5% versus 2%), antithrombin III deficiency (0% versus 0%), lupus anticoagulant (0% versus 0.5%), anticardiolipin antibodies (3% versus 10%; P=0.01), hyperhomocysteinemia (31.5% versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10% versus 5%), and heterocigosis (27.6% versus 41.9%; P=0.01). Conclusion--Prothrombotic conditions were more frequent in stroke of undetermined cause.
Revised on June 17, 2005
Accepted on June 21, 2005
Ischemic Stroke Subtypes and Thrombophilia in Young and Elderly Brazilian Stroke Patients Admitted to a Rehabilitation Hospital
Francisco Javier Carod-Artal MD, PhD*;
Key words: epidemiology • stroke • thrombophilia • thrombosis