Published Online
on August 11, 2005

A more recent version of this article appeared on September 1, 2005

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Submitted on March 24, 2005
Revised on May 15, 2005
Accepted on May 18, 2005

Comparative Overview of Brain Perfusion Imaging Techniques

Max Wintermark MD^*; Musa Sesay MD; Emmanuel Barbier PhD; Katalin Borbély MD, PhD; William P. Dillon MD; James D. Eastwood MD; Thomas C. Glenn MD; Cécile B. Grandin MD, PhD; Salvador Pedraza MD; Jean-François Soustiel MD; Tadashi Nariai MD, PhD; Greg Zaharchuk MD, PhD; Jean-Marie Caillé MD; Vincent Dousset MD; and Howard Yonas MD

From the Department of Radiology (M.W., W.P.D., G.Z.), Neuroradiology Section, University of California, San Francisco; Department of Radiology (M.W.), University Hospital, Lausanne, Switzerland; Department of Neuroradiology (M.S., J.-M.C., V.D.), Pellegrin University Hospital, Bordeaux, France; INSERM (E.B.), Université Joseph Fourier, NeuroImagerie Fonctionnelle et Métabolique, CHU Michallon - Pav. B, Grenoble, France; Department of Nuclear Medicine (K.B.), National Institute of Neurosurgery, Budapest, Hungary; Department of Neuroradiology (J.D.E.), Duke University Medical Center, Durham, NC; Cerebral Blood Flow Laboratory and Brain Injury Research Center (T.C.G.), Division of Neurosurgery, School of Medicine, UCLA Medical Center, Los Angeles, Calif; Department of Radiology (C.B.G.), St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium; Radiology Department (S.P.), IDI, Hospital Dr Josep Trueta, Girona, Spain; Department of Neurosurgery (J.-F.S.), Rambam Medical Center, The Technion, B. Rappaport Faculty of Medicine, Haifa, Israel; Department of Neurosurgery (T.N.), Tokyo Medical and Dental University, Japan; Department of Neurosurgery (H.Y.), University of New Mexico, Albiquerque.

^* To whom correspondence should be addressed. E-mail: Max.Wintermark{at}radiology.ucsf.edu.

Background and Purpose--Numerous imaging techniques have been developed and applied to evaluate brain hemodynamics. Among these are positron emission tomography, single photon emission computed tomography, Xenon-enhanced computed tomography, dynamic perfusion computed tomography, MRI dynamic susceptibility contrast, arterial spin labeling, and Doppler ultrasound. These techniques give similar information about brain hemodynamics in the form of parameters such as cerebral blood flow or cerebral blood volume. All of them are used to characterize the same types of pathological conditions. However, each technique has its own advantages and drawbacks.

Summary of Review--This article addresses the main imaging techniques dedicated to brain hemodynamics. It represents a comparative overview established by consensus among specialists of the various techniques.

Conclusions--For clinicians, this article should offer a clearer picture of the pros and cons of currently available brain perfusion imaging techniques and assist them in choosing the proper method for every specific clinical setting.

Key words: computed tomography • magnetic resonance imaging • tomography, emission computed • ultrasonography, Doppler, transcranial • perfusion • stroke • tomography, emission-computed, single-photon

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