Published Online
on September 15, 2005

A more recent version of this article appeared on October 1, 2005

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Submitted on March 23, 2005
Revised on March 23, 2005
Accepted on April 18, 2005

One-Stage Anterior Approach for Four-Vessel Occlusion in Rat

Mitsuo Yamaguchi MD; John W. Calvert BS; Gen Kusaka MD; and John H. Zhang MD, PhD^*

From the Department of Neurosurgery (M.Y., J.W.C., G.K., J.H.Z.), Louisiana State University Health Sciences Center, Shreveport; Division of Neurosurgery (J.H.Z.) and Department of Physiology (M.Y., J.W.C., J.H.Z.), Loma Linda University, California.

^* To whom correspondence should be addressed. E-mail: johnzhang3910{at}yahoo.com.

Background and Purpose--We report a modified 4-vessel occlusion (4VO) rat model.

Method--We used a 1-stage anterior approach for making bilateral hemispheric ischemia.

Results--Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels.

Conclusion--This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.

Key words: cerebral ischemia, global • cerebral blood flow