Published Online
on September 22, 2005

A more recent version of this article appeared on October 1, 2005

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Submitted on April 7, 2005
Revised on June 8, 2005
Accepted on July 12, 2005

Prevalence of Carotid Artery Stenosis in Patients With Coronary Artery Disease in Japanese Population

Shuzou Tanimoto MD^*; Yuji Ikari MD, PhD; Kengo Tanabe MD, PhD; Sen Yachi MD; Hiroyoshi Nakajima MD, PhD; Tomohiro Nakayama MD; Mitsuharu Hatori MD; Gaku Nakazawa MD; Yoshinobu Onuma MD; Yasutomi Higashikuni MD; Hirosada Yamamoto MD; Eiichi Tooda RMS; and Kazuhiro Hara MD, PhD

From the Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.

^* To whom correspondence should be addressed. E-mail: Shuzou_bushido{at}msn.com.

Background and Purpose--Prevalence of carotid artery stenosis in patients with coronary artery disease (CAD) is unknown in Japanese population.

Methods--The study populations consisted of 632 consecutive patients who underwent coronary angiography because of suspicion of CAD. All patients underwent carotid ultrasonography to screen carotid artery stenosis before coronary angiography. We defined echographic carotid stenosis as area stenosis of >50% or peak systolic velocity of >200 cm/s.

Results--Echographic carotid stenosis was observed in 124 patients (19.6%). Coronary angiography revealed 433 patients had CAD. Prevalence of echographic carotid artery stenosis was 14 of 199 (7.0%), 18 of 124 (14.5%), 28 of 131 (21.4%), and 64 of 178 (36.0%) in patients with 0-, 1-, 2-, and 3-vessel CAD, respectively (P<0.0001). The prevalence rate with carotid stenosis and CAD was 25.4%. Multivariate stepwise logistic regression analysis showed that age and the extent of CAD were independently related to the presence of carotid stenosis (P=0.0002 and <0.0001, respectively).

Conclusions--Prevalence of carotid stenosis in patients with CAD is high in Japan as well as in Western countries. Screening of carotid artery stenosis is recommended especially in older patients with multivessel CAD.

Key words: carotid stenosis • coronary artery disease • epidemiology • Japan

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