Published Online
on October 6, 2005

A more recent version of this article appeared on November 1, 2005

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Submitted on June 8, 2005
Revised on June 8, 2005
Accepted on July 18, 2005

Apolipoprotein E Genotype and Incident Ischemic Stroke. The Atherosclerosis Risk in Communities Study

Jared D. Sturgeon BS; Aaron R. Folsom MD^*; Molly S. Bray PhD; Eric Boerwinkle PhD; Christie M. Ballantyne MD; for the Atherosclerosis Risk in Communities Study Investigators

From the Division of Epidemiology and Community Health (J.D.S., A.R.F.), University of Minnesota, Minneapolis; Departments of Pediatrics (M.S.B.) and Medicine (C.M.B.), Baylor College of Medicine, Houston, Tex; Human Genetics Center (E.B.), University of Texas-Houston Health Science Center, Houston, TX; and Institute of Molecular Medicine (E.B.), University of Texas, Austin.

^* To whom correspondence should be addressed. E-mail: folsom{at}epi.umn.edu.

Background and Purpose--A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC).

Methods--The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred.

Results--After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for 2 genotype relative to 3/3=0.53; 95% CI, 0.28 to 0.99).

Conclusions--For the most part, in this middle-aged sample, apoE was not a risk factor for incident ischemic stroke.

Key words: apolipoprotein E • ischemia • stroke

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