Published Online
on December 1, 2005

A more recent version of this article appeared on January 1, 2006

This Article Full Text (PDF) All Versions of this Article: 37/1/69    most recent 01.STR.0000194961.17292.33v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakayama, T. Articles by Soma, M. Search for Related Content PubMed PubMed Citation Articles by Nakayama, T. Articles by Soma, M. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Related Collections Clinical genetics Acute Cerebral Infarction Genetics of Stroke

Submitted on July 26, 2005
Revised on September 20, 2005
Accepted on October 17, 2005

Genotype and Haplotype Association Study of the STRK1 Region on 5q12 Among Japanese. A Case-Control Study

Tomohiro Nakayama MD, PhD^*; Satoshi Asai MD, PhD; Naoyuki Sato BAgr; and Masayoshi Soma MD, PhD

From the Divisions of Receptor Biology (T.N., N.S.) and Genomic Epidemiology and Clinical Trials (S.A.), Advanced Medical Research Center, and Division of Nephrology and Endocrinology (M.S.), Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

^* To whom correspondence should be addressed. E-mail: tnakayam{at}med.nihon-u.ac.jp.

Background and Purpose--Cerebral infarction is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. Gretarsdottir et al identified a candidate locus (STRK1) for cerebral infarction with a significant logarithm of odds score at 5q12 in whites in 2002 and subsequently identified the PDE4D gene as a susceptibility gene at this locus in 2003. The aims of this haplotype-based case-control study were to confirm, using microsatellite markers and single-nucleotide polymorphisms (SNPs), whether PDE4D is also a susceptibility gene for cerebral infarction in Japanese subjects.

Methods--Cerebral infarction was defined as noncardiogenic ischemic stroke with signs and symptoms lasting >1 month in duration. We genotyped 208 Japanese cerebral infarction patients and 270 non-cerebral infarction controls for 31 SNPs, 3 dinucleotide microsatellites, and 1 tetranucleotide variable number of tandem repeat. Haplotypes were constructed and their frequencies compared between the cerebral infarction patients and the controls.

Results--The haplotype-based case-control study revealed that in addition to the region of the PDE4D gene (P=0.002), another region (P<0.001) also existed within the STRK1 locus.

Conclusions--The region of the PDE4D gene and the other newly detected region within the STRK1 locus were associated with cerebral infarction.

Key words: case-control studies • cerebral infarction • genetics • haplotypes

This article has been cited by other articles:

				L. Wu, Y. Shen, X. Liu, X. Ma, B. Xi, J. Mi, K. Lindpaintner, X. Tan, and X. Wang The 1425G/A SNP in PRKCH Is Associated With Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population Stroke, September 1, 2009; 40(9): 2973 - 2976. [Abstract] [Full Text] [PDF]

				T. Matsushita, M. Kubo, K. Yonemoto, T. Ninomiya, K. Ashikawa, B. Liang, J. Hata, Y. Doi, T. Kitazono, S. Ibayashi, et al. Lack of Association Between Variations of PDE4D and Ischemic Stroke in the Japanese Population Stroke, April 1, 2009; 40(4): 1245 - 1251. [Abstract] [Full Text] [PDF]

				M.-S. Hsieh, S.-C. Yu, W.-T. Chung, Y.-M. Hsueh, F.-C. Chen, W.-T. Chiu, and H.-M. Lee Phosphodiesterase 4D (PDE4D) Gene Variants and Risk of Ischemic Stroke in the Taiwanese Population Lab Med, February 1, 2009; 40(2): 87 - 90. [Abstract] [Full Text] [PDF]

				S. Bevan, M. Dichgans, A. Gschwendtner, G. Kuhlenbaumer, E.B. Ringelstein, and H. S. Markus Variation in the PDE4D Gene and Ischemic Stroke Risk: A Systematic Review and Meta-analysis on 5200 Cases and 6600 Controls Stroke, July 1, 2008; 39(7): 1966 - 1971. [Abstract] [Full Text] [PDF]

				M. Dichgans and R. A. Hegele Update on the Genetics of Stroke and Cerebrovascular Disease 2006 Stroke, February 1, 2007; 38(2): 216 - 218. [Full Text] [PDF]

				J M Staton, M S Sayer, G J Hankey, J Attia, A Thakkinstian, Q Yi, V J Cole, R Baker, and J W Eikelboom Association between phosphodiesterase 4D gene and ischaemic stroke. J. Neurol. Neurosurg. Psychiatry, September 1, 2006; 77(9): 1067 - 1069. [Abstract] [Full Text] [PDF]

				Q. Song, J. W. Cole, J. R. O'Connell, O. C. Stine, M. Gallagher, W. H. Giles, B. D. Mitchell, M. A. Wozniak, B. J. Stern, J. D. Sorkin, et al. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study Hum. Mol. Genet., August 15, 2006; 15(16): 2468 - 2478. [Abstract] [Full Text] [PDF]

				R. Y.L. Zee, V. H. Brophy, S. Cheng, H. H Hegener, H. A. Erlich, and P. M Ridker Polymorphisms of the Phosphodiesterase 4D, cAMP-Specific (PDE4D) Gene and Risk of Ischemic Stroke: A Prospective, Nested Case-Control Evaluation Stroke, August 1, 2006; 37(8): 2012 - 2017. [Abstract] [Full Text] [PDF]

				B. B. Worrall and J. C. Mychaleckyj PDE4D and Stroke: A Real Advance or a Case of the Emperor's New Clothes? Stroke, August 1, 2006; 37(8): 1955 - 1957. [Full Text] [PDF]

				V. H. Brophy, S. K. Ro, B. K. Rhees, L.-Y. Lui, J. M. Lee, N. Umblas, L. G. Bentley, J. Li, S. Cheng, W. S. Browner, et al. Association of Phosphodiesterase 4D Polymorphisms With Ischemic Stroke in a US Population Stratified by Hypertension Status Stroke, June 1, 2006; 37(6): 1385 - 1390. [Abstract] [Full Text] [PDF]