Published Online
on November 23, 2005

A more recent version of this article appeared on January 1, 2006

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Submitted on June 7, 2005
Revised on July 13, 2005
Accepted on July 27, 2005

Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke. The Northern Manhattan Study

Mitchell S.V. Elkind MD, MS^*; Robert Sciacca DEngSc; Bernadette Boden-Albala Dr PH; Tanja Rundek MD, PhD; Myunghee C. Paik PhD; and Ralph L. Sacco MD, MS

From the Department of Neurology (M.S.V.E., T.R., R.L.S.), Columbia University College of Physicians and Surgeons, New York, NY; Gertrude H. Sergievsky Center (M.S.V.E., B.B.-A., R.L.S.), Columbia University, New York, NY; Department of Medicine (R.S.), Columbia University College of Physicians and Surgeons, New York, NY; Department of Sociomedical Sciences (B.B.-A.), Joseph Mailman School of Public Health, New York, NY; Department of Epidemiology (M.C.P., R.L.S.), Joseph Mailman School of Public Health, New York, NY; and Department of Biostatistics (M.C.P.), Joseph Mailman School of Public Health, New York, NY.

^* To whom correspondence should be addressed. E-mail: mse13{at}columbia.edu.

Background and Purpose--Moderate alcohol consumption is protective against coronary disease, but its relationship to ischemic stroke (IS) is controversial.

Methods--Stroke-free participants 40 years of age identified by random-digit dialing were enrolled in a prospective cohort study between 1993 and 2001. Alcohol consumption was assessed through in-person interview and categorized as none in the past year, 1 drink in past month to 2 per day (moderate drinkers), and >2 drinks daily. Lifetime drinking was also assessed. Cox proportional hazard regression modeling was used to assess hazard ratios and their 95% CIs for the association of drinking with risk of stroke and vascular events.

Results--Mean age among participants (n=3176) was 69.1±10.3 years; 62.8% were women, 20.8% were non-Hispanic white, 24.5% non-Hispanic black, and 52.4% were Hispanic. No alcohol in the previous year was present in 62.3%, and 32.5% drank moderately. After adjusting for other risk factors compared with those who did not drink in the past year, moderate drinkers had a reduced risk of IS (0.67; 95% CI, 0.46 to 0.99) and IS, myocardial infarction, or vascular death (0.74; 95% CI, 0.59 to 0.94). Results were similar when never-drinkers were used as referent group. Reduction in risk was seen for nonatherosclerotic IS subtypes, and results stratified by age, sex, and race-ethnicity were similar.

Conclusion--Moderate alcohol consumption is associated with decreased risk of IS in a multiethnic population. This effect is independent of other risk factors and holds for nonatherosclerotic stroke subtypes.

Key words: alcohol • cerebrovascular disorders • epidemiology • risk factors • stroke, ischemic

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Larry B. Goldstein
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