on December 1, 2005
Published online before print December 1, 2005, doi: 10.1161/01.STR.0000195130.16843.ac
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Submitted on May 31, 2005
From the Human Cortical Physiology Section (L.S., C.W.-H.W., A.K.-L., L.G.C.) National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, Md; Department of Neurology (L.S.), Program in Rehabilitation, Wake Forest University, Winston-Salem, NC; Department of Neurology (A.K.-L.), Motor Laboratory and Movement Disorders Center, University Hospital Inselspital, Bern Switzerland. * To whom correspondence should be addressed. E-mail: lsawaki{at}wfubmc.edu.
Background and Purpose--There is a need to develop strategies to enhance the beneficial effects of motor training, including use-dependent plasticity (UDP), in neurorehabilitation. Peripheral nerve stimulation (PNS) modulates motor cortical excitability in healthy humans and could influence training effects in stroke patients. Methods--We compared the ability of PNS applied to the (1) arm, (2) leg, and (3) idle time to influence training effects in the paretic hand in 7 chronic stroke patients. The end point measure was the magnitude of UDP. Results--UDP was more prominent with arm stimulation (increased by 22.8%) than with idle time (by 2.9%) or leg stimulation (by 6.4%). Conclusions--PNS applied to the paretic limb paired with motor training enhances training effects on cortical plasticity in stroke patients.
Revised on September 26, 2005
Accepted on October 14, 2005
Effects of Somatosensory Stimulation on Use-Dependent Plasticity in Chronic Stroke
Lumy Sawaki MD, PhD*;
Key words: nerve stimulation • neuronal plasticity • stroke • stimulation, transcranial magnetic
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