Published Online
on December 1, 2005

A more recent version of this article appeared on January 1, 2006

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Submitted on August 1, 2005
Accepted on October 9, 2005

Reduced Vitamin D in Acute Stroke

Kenneth E.S. Poole BM, MRCP^*; Nigel Loveridge PhD; Peter J. Barker MSc; David J. Halsall PhD, MRCPath; Collette Rose; Jonathan Reeve DM, BSc, FRCP; and Elizabeth A. Warburton MA, DM, MRCP

From the Department of Medicine, Addenbrooke’s Hospital, Cambridge, UK.

^* To whom correspondence should be addressed. E-mail: kesp2{at}cam.ac.uk.

Background and Purpose--Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke.

Methods--We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling.

Results--The mean Z score of vitamin D in acute stroke was -1.4 SD units (95% CI, -1.7, -1.1), with 77% of patients falling in the insufficient range.

Conclusions--Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.

Key words: rehabilitation • stroke

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