on January 12, 2006
Published online before print January 12, 2006, doi: 10.1161/01.STR.0000199085.40000.cf
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Submitted on October 13, 2005
From the Departments of Strokology (K.Y., A.S., K.N., M.S., J.M.) and Radiology (J.H., E.S.), Research Institute for Brain and Blood Vessels, Akita, Japan. * To whom correspondence should be addressed. E-mail: akifumi{at}akita-noken.go.jp.
Background and Purpose--The present study examined the relationship between circulatory and metabolic reserve in patients with hemodynamic impairment. Methods--Positron emission tomography was used to investigate 40 patients with major cerebral artery occlusive disease. The ratio of cerebral blood volume to cerebral blood flow (CBV/CBF) and vasoreactivity in response to hypercapnia (%CBFhypercapnia) and acetazolamide (ACZ) stress (%CBFACZ) were measured to evaluate circulatory reserve. Oxygen extraction fraction (OEF) was measured to evaluate metabolic reserve. To detect relationships between circulation reserve and OEF, cerebral hemispheres were grouped into 5 or 6 stepwise groups based on reduction of circulation reserve. Results--OEF was significantly elevated in hemispheres with CBV/CBF Conclusions--Metabolic reserve consumption began at CBV/CBF
Accepted on November 3, 2005
Relationship Between Cerebral Circulatory Reserve and Oxygen Extraction Fraction in Patients With Major Cerebral Artery Occlusive Disease. A Positron Emission Tomography Study
Kenichiro Yata MD;
0.11 minutes and in hemispheres with %CBFhypercapnia <0%. OEF was significantly increased according to %CBFACZ in hemispheres with %CBFACZ <15% and plateaued at levels below -15%.0.11 minutes, CBFhypercapnia <0%, and CBFACZ <15%.
Key words: ischemia • tomography, emission computed
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