on January 19, 2006
Published online before print January 19, 2006, doi: 10.1161/01.STR.0000202655.64413.0c
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Submitted on September 28, 2005
From the Department of Neurology, Jagiellonian University, Krakow, Poland. * To whom correspondence should be addressed. E-mail: pera{at}su.krakow.pl.
Background and Purpose--Genetic factors involved in the pathogenesis of primary intracerebral hemorrhage (PICH) remain unknown. One of the candidate genes is SERPINA3. Results of a Spanish study suggested that TT genotype of the A/T SERPINA3 polymorphism in the signal peptide sequence was a risk factor for PICH in normotensive subjects. The aim of the present study was to investigate whether SERPINA3 A/T polymorphism is associated with PICH in a Polish population. Methods--We analyzed 95 PICH patients and 190 unrelated healthy controls matched for age and sex. A/T polymorphism of the SERPINA3 gene was investigated using polymerase chain reaction restriction fragment length polymorphism method. Results--The distribution of SERPINA3 genotypes was similar among PICH patients (AA 27.4%; AT 46.3%; TT 26.3%) and controls (AA 23.7%; AT 50.5%; TT 25.8%; P=NS). There were also no significant differences in genotype distribution when analyzing separately hypertensive and normotensive PICH patients as well as patients with lobar and deeply located hemorrhage. Conclusions--We failed to find an association between SERPINA3 A/T polymorphism and PICH in a Polish population.
Revised on November 9, 2005
Accepted on November 22, 2005
SERPINA3 Polymorphism Is Not Associated With Primary Intracerebral Hemorrhage in a Polish Population
Joanna Pera MD*;
Key words: genetics • intracerebral hemorrhage