Published Online
on March 9, 2006

A more recent version of this article appeared on April 1, 2006

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Submitted on December 21, 2005
Revised on January 25, 2006
Accepted on January 31, 2006

The Risks and Safety of Clopidogrel in Pediatric Arterial Ischemic Stroke

Teesta Soman MD; Mubeen F. Rafay MB, BS; Selina Hune MSc, NP; Anita Allen RN; Daune MacGregor MD; and Gabrielle deVeber MD^*

From the Hospital for Sick Children, Toronto, Canada.

^* To whom correspondence should be addressed. E-mail: Gabrielle.deveber{at}sickkids.ca.

Background and Purpose--The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS). Clopidogrel is the alternative antiplatelet medication when aspirin is not tolerated or fails. The possible risks and safety of clopidogrel in children with AIS have not been assessed.

Methods--This is a prospective consecutive cohort study of children with AIS who were started on clopidogrel. Seventeen children were included.

Results--Two children developed subdural hematomas while on clopidogrel in conjunction with aspirin. Two others had headache or hand numbness. No other side effects like rash or gastrointestinal upsets were reported.

Conclusions--We found clopidogrel to be relatively well tolerated in the pediatric population. In combination with aspirin and in the presence of other risk factors, intracranial bleeding may be seen.

Key words: antiplatelet agents • child • clopidogrel • stroke

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