Published Online
on March 23, 2006

A more recent version of this article appeared on May 1, 2006

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Submitted on January 3, 2006
Accepted on February 1, 2006

Good Outcomes in Ischemic Stroke Patients Treated With Intravenous Thrombolysis Despite Regressing Neurological Symptoms

Christian R. Baumann MD; Ralf W. Baumgartner MD; Joubin Gandjour MD; Hans-Christian von Büdingen MD; Adrian M. Siegel MD; and Dimitrios Georgiadis MD^*

From the Department of Neurology, University of Zürich, Zürich, Switzerland.

^* To whom correspondence should be addressed. E-mail: dimitrios.georgiadis{at}usz.ch.

Background and Purpose--We evaluated the clinical course of 19 acute stroke patients with rapid early improvement of neurological deficit within the 3-hour window, treated with intravenous thrombolytics.

Results--No patient demonstrated a neurological deterioration during hospitalization. National Institutes of Health Stroke Scale (NIHSS) scores at therapy decision and discharge were 5 (4 to 6) and 0.5 (0 to 1.5), respectively. At 3-month follow-up, 1 patient had died; in remaining patients, NIHSS was 0 (0 to 1) and modified Rankin Scale 0.5 (0 to 1; 1 in 15 patients).

Conclusions--Withholding of intravenous thrombolysis because of spontaneous early regression of neurological symptoms may not be justified.

Key words: cerebrovascular disorder • thrombolysis

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