on March 30, 2006
Published online before print March 30, 2006, doi: 10.1161/01.STR.0000217409.60731.38
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Submitted on August 16, 2005
From the Cerebral Vascular Disease Research Center (K.R.D., R.P., A.P.R., M.A.P.-P.), Department of Neurology and Neuroscience, Leonard M. Miller School of Medicine, University of Miami, Florida; and Institute of Arctic Biology (K.L.D.), University of Alaska Fairbanks. * To whom correspondence should be addressed. E-mail: perezpinzon{at}miami.edu.
Background and Purpose--Hetereothermic mammals tolerate hypoxia during euthermy and torpor, and evidence suggests this tolerance may extend beyond hypoxia to cerebral ischemia. During hibernation, CA1 hippocampal neurons endure extreme fluctuations in cerebral blood flow during transitions into and out of torpor as well as reductions in cerebral blood flow during torpor. In vitro studies likewise show evidence of ischemia tolerance in hippocampal slices harvested from euthermic ground squirrels; however, no studies have investigated tolerance in a clinically relevant model of in vivo global cerebral ischemia. The purpose of the present study was to test the hypothesis that the euthermic Arctic ground squirrel (AGS; Spermophillus parryii) is resistant to injury from asphyxial cardiac arrest (CA). Methods--Estrous-matched female rats were used as a positive control. Female euthermic AGS and rats were subjected to 8-minute CA. At the end of 7 days of reperfusion, AGS and rats were fixed for histopathological assessment. Results--In rats subjected to CA, the number of ischemic neurons was significantly higher (P<0.001) compared with control rats in hippocampus and striatum. Cortex was mildly injured. Surprisingly, neuronal counts in AGS were not significantly different in CA and control groups in these brain regions. Conclusion--These data demonstrate that AGS are remarkably tolerant to global cerebral ischemia during euthermia. A better understanding of the mechanisms by which AGS tolerate severe reductions in blood flow during euthermia may provide novel neuroprotective strategies that may translate into significant improvements in human patient outcomes after CA.
Revised on November 15, 2005
Accepted on December 7, 2005
The Arctic Ground Squirrel Brain Is Resistant to Injury From Cardiac Arrest During Euthermia
Kunjan R. Dave PhD;
Key words: cerebral ischemia • heart arrest • neuroprotection
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