Published Online
on April 20, 2006

A more recent version of this article appeared on June 1, 2006

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Submitted on December 23, 2005
Revised on February 27, 2006
Accepted on March 8, 2006

Recommendations of the National Heart, Lung, and Blood Institute Working Group on Cerebrovascular Biology and Disease

Costantino Iadecola MD; Stephen S. Goldman PhD^*; David R. Harder PhD; Donald D. Heistad MD; Zvonimir S. Katusic MD, PhD; Michael A. Moskowitz MD; J. Marc Simard MD, PhD; Michael A. Sloan MD; Richard J. Traystman PhD; and Paul A. Velletri PhD

From the Weill Cornell Medical College, New York, NY (C.I.); the National Heart, Lung, and Blood Institute, Bethesda, MD (S.S.G., P.A.V.); Medical College of Wisconsin, Milwaukee, WI (D.H.); University of Iowa, Iowa City, IA (D.D.H.); Mayo Clinic College of Medicine, Rochester, MN (Z.S.K.); Massachusetts General Hospital, Charlestown, MA (M.A.M.), University of Maryland Medical School, Baltimore, MD (J.M.S.); Carolinas Medical Center, Charlotte, NC (M.A.S.); Oregon Health and Science University School of Medicine, Portland, OR (R.J.T.).

^* To whom correspondence should be addressed. E-mail: goldmans{at}nhlbi.nih.gov.

Abstract--The National Heart, Lung, and Blood Institute (NHLBI) convened a conference call working group, consisting of experts in stroke and cerebrovascular biology on January 28, 2005. The purpose of this working group was to develop a prioritized set of recommendations for NHLBI to establish a focused and comprehensive set of research activities in cerebrovascular biology and disease. Three thematic areas of research emerged: (1) molecular and cellular neurobiology of cerebral blood vessels, focusing on genomics and proteomics, neurovascular signaling and cerebrovascular embryogenesis, development and plasticity; (2) resource development, involving the development of new methodological approaches for normal and altered function of the neurovascular unit, collaborative research, and training in cerebrovascular pathobiology; and (3) cerebrovascular diseases and translational approaches, addressing vascular mechanisms of disease, the role of risk factors, importance of biomarkers with the ultimate goal of developing new treatments.

Key words: cerebrovascular disease • microcirculation

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