Published Online
on May 25, 2006

A more recent version of this article appeared on July 1, 2006

This Article Full Text (PDF) All Versions of this Article: 37/7/1674    most recent 01.STR.0000226979.56456.a8v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Benatru, I. Articles by Giroud, M. Search for Related Content PubMed PubMed Citation Articles by Benatru, I. Articles by Giroud, M. Related Collections Risk Factors Acute Stroke Syndromes Primary and Secondary Stroke Prevention Risk Factors for Stroke Anticoagulants Antiplatelets Epidemiology

Submitted on September 14, 2005
Revised on March 29, 2006
Accepted on April 13, 2006

Stable Stroke Incidence Rates but Improved Case-Fatality in Dijon, France, From 1985 to 2004

Isabelle Benatru MD; Olivier Rouaud MD; Jérôme Durier PhD; Fabienne Contegal MD; Grégory Couvreur MD; Yannick Bejot MD; Guy Victor Osseby MD; Douraïeb Ben Salem MD; Frédéric Ricolfi MD; Thibault Moreau MD; and Maurice Giroud MD^*

From the Stroke Registry of Dijon (Inserm and Institut de Veille Sanitaire). Faculty of Medicine and University Hospital of Dijon - France.

^* To whom correspondence should be addressed. E-mail: maurice.giroud{at}chu-dijon.fr..

Background and Purpose--With the progress in stroke prevention, it is important to evaluate the epidemiological trends of strokes over a long period and from a nonselected population-based perspective.

Methods--We estimated changes in incidence, case-fatality rates, severity, risk factors and prestroke use of preventive treatments for first-ever strokes, from a continuous 20-year well-defined population-based registry, from 1985 to 2004.

Results--We recorded 3142 ischemic strokes, 341 primary cerebral hemorrhages and 74 subarachnoid hemorrhages. During the 20-year study, the age at first stroke onset increased by 5 years in men and 8 years in women. Comparing the 1985 to 1989 and the 2000 to 2004 periods, age- and sex-standardized incidences of first-ever strokes were stable except for lacunar strokes whose incidence significantly increased (P=0.01) and for cardioembolic stroke whose incidence significantly decreased (P=0.01). Twenty-eight-day case-fatality rates decreased significantly mainly for lacunar strokes (P=0.05) and for primary cerebral hemorrhages (P=0.03). The proportion of hypercholesterolemia and diabetes significantly increased (P<0.01). In contrast, the proportion of myocardial infarction significantly decreased (P=0.02). Prestroke antiplatelets and anticoagulants treatment significantly increased (P<0.01).

Conclusions--The age- and sex-standardized incidences of first strokes in Dijon have been stable over the past 20 years and were associated with an increase in age at stroke onset, a decrease in case-fatality rates, and an increased use of antiplatelet treatments.

Key words: cerebrovascular accident • epidemiology • incidence • risk factors • stroke

This article has been cited by other articles:

				A Gentil, Y Bejot, L Lorgis, J Durier, M Zeller, G-V Osseby, G Dentan, J-C Beer, T Moreau, M Giroud, et al. Comparative epidemiology of stroke and acute myocardial infarction: the Dijon Vascular project (Diva) J. Neurol. Neurosurg. Psychiatry, September 1, 2009; 80(9): 1006 - 1011. [Abstract] [Full Text] [PDF]

				J. D. Lewsey, P. S. Jhund, M. Gillies, J. W.T. Chalmers, A. Redpath, L. Kelso, A. Briggs, M. Walters, P. Langhorne, S. Capewell, et al. Age- and Sex-Specific Trends in Fatal Incidence and Hospitalized Incidence of Stroke in Scotland, 1986 to 2005 Circ Cardiovasc Qual Outcomes, September 1, 2009; 2(5): 475 - 483. [Abstract] [Full Text] [PDF]

				The European Registers of Stroke (EROS) Investigat Incidence of Stroke in Europe at the Beginning of the 21st Century Stroke, May 1, 2009; 40(5): 1557 - 1563. [Abstract] [Full Text] [PDF]

				P. Appelros, B. Stegmayr, and A. Terent Sex Differences in Stroke Epidemiology: A Systematic Review Stroke, April 1, 2009; 40(4): 1082 - 1090. [Abstract] [Full Text] [PDF]

				J. D. Lewsey, M. Gillies, P. S. Jhund, J. W.T. Chalmers, A. Redpath, A. Briggs, M. Walters, P. Langhorne, S. Capewell, J. J.V. McMurray, et al. Sex Differences in Incidence, Mortality, and Survival in Individuals With Stroke in Scotland, 1986 to 2005 Stroke, April 1, 2009; 40(4): 1038 - 1043. [Abstract] [Full Text] [PDF]

				S. Paolucci Escitalopram and problem solving therapy reduce the incidence of post-stroke depression Evid. Based Ment. Health, February 1, 2009; 12(1): 10 - 10. [Full Text] [PDF]

				Y. Bejot, D. B. Salem, G. V. Osseby, G. Couvreur, J. Durier, C. Marie, Y. Cottin, T. Moreau, and M. Giroud Epidemiology of ischemic stroke from atrial fibrillation in Dijon, France, from 1985 to 2006 Neurology, January 27, 2009; 72(4): 346 - 353. [Abstract] [Full Text] [PDF]

				Y Bejot, M Caillier, D Ben Salem, G Couvreur, O Rouaud, G-V Osseby, J Durier, C Marie, T Moreau, and M Giroud Ischaemic stroke subtypes and associated risk factors: a French population based study J. Neurol. Neurosurg. Psychiatry, December 1, 2008; 79(12): 1344 - 1348. [Abstract] [Full Text] [PDF]

				G. Manobianca, S. Zoccolella, A. Petruzzellis, A. Miccoli, and G. Logroscino Low Incidence of Stroke in Southern Italy: A Population-Based Study Stroke, November 1, 2008; 39(11): 2923 - 2928. [Abstract] [Full Text] [PDF]

				P. U. Heuschmann, A. P. Grieve, A. M. Toschke, A. G. Rudd, and C. D.A. Wolfe Ethnic Group Disparities in 10-Year Trends in Stroke Incidence and Vascular Risk Factors: The South London Stroke Register (SLSR) Stroke, August 1, 2008; 39(8): 2204 - 2210. [Abstract] [Full Text] [PDF]

				Y. Bejot, A. Catteau, M. Caillier, O. Rouaud, J. Durier, C. Marie, A. Di Carlo, G.-V. Osseby, T. Moreau, and M. Giroud Trends in Incidence, Risk Factors, and Survival in Symptomatic Lacunar Stroke in Dijon, France, From 1989 to 2006: A Population-Based Study Stroke, July 1, 2008; 39(7): 1945 - 1951. [Abstract] [Full Text] [PDF]

				Md. S. Islam, C. S. Anderson, G. J. Hankey, K. Hardie, K. Carter, R. Broadhurst, and K. Jamrozik Trends in Incidence and Outcome of Stroke in Perth, Western Australia During 1989 to 2001: The Perth Community Stroke Study Stroke, March 1, 2008; 39(3): 776 - 782. [Abstract] [Full Text] [PDF]

				B. Hallstrom, A.-C. Jonsson, C. Nerbrand, B. Norrving, and A. Lindgren Stroke Incidence and Survival in the Beginning of the 21st Century in Southern Sweden: Comparisons With the Late 20th Century and Projections Into the Future Stroke, January 1, 2008; 39(1): 10 - 15. [Abstract] [Full Text] [PDF]

				R. Carandang, S. Seshadri, A. Beiser, M. Kelly-Hayes, C. S. Kase, W. B. Kannel, and P. A. Wolf Trends in Incidence, Lifetime Risk, Severity, and 30-Day Mortality of Stroke Over the Past 50 Years JAMA, December 27, 2006; 296(24): 2939 - 2946. [Abstract] [Full Text] [PDF]