Published Online
on June 22, 2006

A more recent version of this article appeared on August 1, 2006

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Submitted on March 10, 2006
Revised on May 10, 2006
Accepted on May 23, 2006

Intravenous Recombinant Tissue Plasminogen Activator in a Pregnant Woman With Cardioembolic Stroke

Kathleen M. Wiese DO^*; Arun Talkad MD; Maureen Mathews APN; and David Wang DO

From the Department of Neurology (K.M.W., A.T.), University of Illinois at Peoria; and the OSF Stroke Center and Network (M.M., D.W.), Illinois Neurological Institute, OSF St. Francis Medical Center, Peoria, Ill.

^* To whom correspondence should be addressed. E-mail: kathleenwiese{at}yahoo.com.

Background and Purpose--Historically, the use of tissue plasminogen activator (tPA) thrombolysis in pregnancy has been regarded as relatively contraindicated. Underlying this stance has been the concern over the risk of bleeding complications in both mother and child.

Summary of Case--We report the successful use of intravenous recombinant tPA (rtPA) thrombolysis in a pregnant woman with acute cardioembolic stroke.

Conclusions--The patient improved clinically, did not develop complications after receiving rtPA, and at 37 weeks’ gestation, delivered a healthy infant, demonstrating that rtPA thrombolysis may be used safely in pregnant women.

Key words: thrombolysis • tissue plasminogen activator

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