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Published Online
on September 28, 2006

Stroke. 2006
Published online before print September 28, 2006, doi: 10.1161/01.STR.0000244764.02851.d3
A more recent version of this article appeared on November 1, 2006
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Submitted on April 14, 2006
Accepted on June 15, 2006

Homocysteine and Carotid Intima-Media Thickness in a German Population. Lack of Clinical Relevance

Michael Linnebank MD*; Susanna Moskau MD; Susan Farmand; Klaus Fliessbach MD; Heike Kölsch PhD; Monika Bös MD; Christoph Grothe MD; Dietmar Becker MD; Ursula Harbrecht MD; Christoph Pohl MD; Ullrich Wüllner MD, PhD; and Thomas Klockgether MD

From the Departments of Neurology (M.L., S.M., S.F., M.B., C.G., D.B., C.P., U.W., T.K.), Epileptology (K.F.), Psychiatry (H.K.), and Transfusion Medicine (U.H.), University Hospital Bonn, Bonn, Germany.

* To whom correspondence should be addressed. E-mail: Michael.Linnebank{at}ukb.uni-bonn.de.

Background and Purpose--Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT.

Methods--We analyzed the association of personal, clinical, and biochemical data (multivariate analysis) and of 9 polymorphisms involved in Hcys metabolism (ANOVA) with CCA IMT in 714 individuals of 187 families.

Results--CCA IMT was significantly predicted by age, sex, creatinine levels, lipoprotein(a) levels, pack-years of smoking, the presence of hypertension, and the presence of diabetes mellitus but not by Hcys levels. Homozygosity for the T allele of the polymorphism methylenetetrahydrofolate reductase c.677C>T was significantly associated with higher Hcys levels but not with a higher CCA IMT.

Conclusions--These data do not support the thesis that elevated Hcys levels are causally involved in cerebrovascular disease.
Key words: carotid intima-media thickness • carotid ultrasound • genetics • homocysteinemia • stroke




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[Abstract] [Full Text] [PDF]


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