on September 21, 2006
Published online before print September 21, 2006, doi: 10.1161/01.STR.0000244782.76917.87
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Submitted on July 10, 2006
From the Ilsong Institute of Life Science, Hallym University, South Korea. * To whom correspondence should be addressed. E-mail: clee{at}hallym.ac.kr.
Background and Purpose--Transforming growth factor- Methods--Three sequence variants in and around promoter and exons of TGFB1 gene were identified in 30 Koreans. Pro10Leu was selected for association study, and then control subjects (n=207) and patients with ischemic stroke (n=271) and vascular dementia (n=207) were screened. Results--Subjects carrying Leu/Leu were susceptible to both ischemic stroke (odds ratio [OR]=1.63; P<0.05) and vascular dementia (OR=1.88; P<0.01). Analyses with stroke subtypes showed a strong association with small vessel occlusion (SVO, n=110; OR=2.07; P<0.01). Further analysis of SVO data partitioned by gender revealed the female-specific association with Pro10Leu (OR=2.70; P<0.05). Conclusions--The Pro10Leu of TGFB1 might be a risk factor of ischemic stroke and vascular dementia, especially for SVO in females.
Revised on July 22, 2006
Accepted on August 17, 2006
The Gene Encoding Transforming Growth Factor
Younyoung Kim PhD and Chaeyoung Lee PhD*
1 Confers Risk of Ischemic Stroke and Vascular Dementia
1 (TGF-1) is an anti-inflammatory cytokine that plays an important role in cerebrovascular pathophysiology with protective activity against ischemia-induced neuronal death. We investigated the association of the polymorphism in TGFB1 with ischemic stroke and vascular dementia.
Key words: genetics • ischemia
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