Published Online
on September 28, 2006

A more recent version of this article appeared on November 1, 2006

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Submitted on June 6, 2006
Accepted on August 1, 2006

Candidate Gene Polymorphisms Do Not Differ Between Newborns With Stroke and Normal Controls

Steven P. Miller MD, MAS^*; Yvonne W. Wu MD, MPH; Janet Lee MD; Edward J. Lammer MD; David M. Iovannisci MS, PhD; David V. Glidden PhD; Sonia L. Bonifacio MD; Abigail Collins MD; Gary M. Shaw DrPH; A. James Barkovich MD; and Donna M. Ferriero MD

From the Departments of Neurology (S.P.M., Y.W.W., J.L., S.L.B., A.C., A.J.B., D.M.F.), Pediatrics (S.P.M., Y.W.W., J.L., S.L.B., A.C., A.J.B., D.M.F.), Epidemiology and Biostatistics (D.V.G.), and Radiology (A.J.B.), University of California, San Francisco, California; the Children’s Hospital Oakland Research Institute (E.J.L., D.M.I.), Oakland, California; the California Birth Defects Monitoring Program (G.M.S.), March of Dimes Birth Defects Foundation, Berkeley, California; and the Department of Pediatrics (Neurology) (S.P.M.), University of British Columbia, Vancouver, BC, Canada.

^* To whom correspondence should be addressed. E-mail: MillerSt{at}neuropeds.ucsf.edu.

Background and Purpose--Neonatal stroke is increasingly recognized with an estimated incidence of one in 4000 live births per year. Pathways involved in the pathophysiology of neonatal stroke are diverse and may include thrombosis and thrombolysis, vascular reactivity, and inflammation.

Methods--We compared frequencies of polymorphisms in genes regulating thrombosis and thrombolysis, nitric oxide, cytokines, vascular tone, and cell adhesion in a hospital-based cohort of 59 newborns with stroke relative to a random sample of 437 California newborns.

Results--Of the 31 polymorphisms evaluated, no variant allele was significantly more common than the reference allele in newborns with stroke than in the general population.

Conclusions--Using a series of polymorphisms in pathways implicated in the etiology of stroke, newborns with stroke were not distinguished from a normal control group. Further studies are needed to determine the interaction of genetic polymorphisms with environmental risk factors in the pathogenesis of neonatal stroke.

Key words: brain infarction • cerebral infarct • cerebral venous thrombosis • clinical • etiology • genetics • neonatal ischemia • pediatric neurology • risk factors • sinus thrombosis • stroke in children • thrombosis • young, stroke in

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