on November 2, 2006
Published online before print November 2, 2006, doi: 10.1161/01.STR.0000248760.67039.2b
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Submitted on March 23, 2006
From the Departments of Epidemiology and Biostatistics (M.J.E.v.R., M.J.B., M.Y., A.I., A.A.-V., A.H., J.C.W., C.M.v.D., M.M.B.B.) and Neurology (M.J.B., P.J.K.), Erasmus Medical Center, Rotterdam, The Netherlands. * To whom correspondence should be addressed. E-mail: m.breteler{at}erasmusmc.nl.
Background and Purpose--Carriers of the 460Trp allele of the Methods--Intima-media thickness of the common carotid artery, as well as incident stroke and myocardial infarction, were studied within 6471 subjects of the Rotterdam Study. Within 1018 subjects of the Rotterdam Scan Study, prevalent silent brain infarcts and cerebral white matter lesions were studied. Subjects were grouped into 460Trp carriers (variant carriers) and homozygous carriers of the Gly460 allele (reference). Results--Intima-media thickness of the common carotid artery was 0.80 mm in variant carriers compared with 0.79 mm in the reference group (P=0.04). Variant carriers had an increased risk of any stroke (hazard ratio [HR], 1.22; 95% CI, 1.02 to 1.45), ischemic stroke (HR, 1.29; 95% CI, 1.02 to 1.63), hemorrhagic stroke (HR, 1.07; 95% CI, 0.59 to 1.92), and of myocardial infarction (HR, 1.33; 95% CI, 1.05 to 1.69). For any ischemic stroke, there was a significant interaction between the Gly460Trp polymorphism and hypertension. Variant carriers more often had a silent brain infarct (odds ratio, 1.36; 95% CI, 0.98 to 1.88) and had more subcortical white matter lesions than the reference group (1.45 vs1.24 mL; P=0.22). Conclusions--The Gly460Trp polymorphism is associated with atherosclerosis, cardiovascular disease, and cerebrovascular disease, especially in hypertensive subjects.
Revised on June 9, 2006
Accepted on July 18, 2006
Marie Josee E. van Rijn MSc; 
-Adducin Polymorphism, Atherosclerosis, and Cardiovascular and Cerebrovascular Risk
-adducin gene (ADD1) show higher rates of sodium reabsorption compared with homozygous carriers of the Gly460 allele and were found to have an increased risk of hypertension and cardiovascular disease. We studied the association between the Gly460Trp polymorphism and atherosclerosis, cardiovascular disease, and cerebrovascular disease.
Key words: agr;-adducin • atherosclerosis • cardiovascular disease • cerebrovascular disease • polymorphism
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