on February 22, 2007
Published online before print February 22, 2007, doi: 10.1161/01.STR.0000259816.31370.44
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Submitted on October 5, 2006
From Department of Neurology, University Hospitals Leuven, Leuven, Belgium. * To whom correspondence should be addressed. E-mail: vincent.thijs{at}uz.kuleuven.ac.be.
Background and Purpose--Apolipoprotein E (apoE) alleles ( Methods--We obtained brain MRI scans and apoE genotypes in 334 transient ischemic attack or ischemic stroke patients. Microbleeds were scored on a gradient echo MRI and white matter disease was examined on fluid attenuated inversion recovery MRI using a semiquantitative rating scale. Results--Patients with moderate to severe white matter disease more frequently carried apoE Conclusions--ApoE alleles do not exert a major influence on the development of microbleeds, but apoE
Revised on November 9, 2006
Accepted on November 17, 2006
Association of Apolipoprotein E
Robin Lemmens MD; 
2 With White Matter Disease but Not With Microbleeds
2 and 4) are associated with cerebral amyloid angiopathy, in which white matter disease and microbleeds are prominent features. The role of apoE in patients with and microbleeds or white matter disease but no evidence of cerebral amyloid angiopathy has not been elucidated. We studied apoE alleles in relation to white matter disease and microbleeds in patients with transient ischemic attack or ischemic stroke.2 alleles (25.2% versus 11.3%, P=0.001), but not apoE 4 (26.6% in apoE 4 carriers versus 25.9%; P=0.98). Adjustment for traditional risk factors did not modify this relationship (odds ratio, 2.9; 95% confidence interval, 1.5 to 5.3). There was no association between the presence of microbleeds and the apoE 4 or apoE 2 alleles.2 may be associated with development of moderate to severe white matter disease in transient ischemic attack and stroke patients.
Key words: apolipoprotein E • genetics • white matter
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