Published Online
on March 1, 2007

A more recent version of this article appeared on April 1, 2007

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Submitted on September 18, 2006
Revised on November 9, 2006
Accepted on November 23, 2006

Autopsy Prevalence of Coronary Atherosclerosis in Patients With Fatal Stroke

Fernando Gongora-Rivera MD; Julien Labreuche BS; Arturo Jaramillo MD; Philippe Gabriel Steg MD; Jean-Jacques Hauw MD; and Pierre Amarenco MD^*

From Department of Neuropathology Raymond Escourolle (F.G.-R., A.J., J.-J.H., P.A.), La Salpêtrière Hospital, France; Department of Neurology and Stroke Centre (F.G.-R., J.L., A.J., P.A.), Bichat University Hospital, Paris, France; Department of Cardiology (P.G.S.), Bichat University Hospital, Denis Diderot University and Medical School, Paris, France.

^* To whom correspondence should be addressed. E-mail: pierre.amarenco{at}bch.aphp.fr.

Background and Purpose--Myocardial infarction (MI) is the leading cause of long-term mortality in patients with stroke, yet the prevalence of coronary atherosclerosis in these individuals is unknown. The objective of the study was to establish the prevalence of coronary atherosclerosis and MI after fatal stroke.

Methods--Using an autopsy data bank, we studied the prevalence of coronary plaques and coronary stenoses >50% and pathologic evidence of MI in 803 consecutive autopsies of neurologic patients.

Results--Coronary plaques, coronary stenoses, and MI were present in 72.4%, 37.5%, and 40.8%, respectively, of the 341 patients with stroke and in 26.8%, 10.1%, and 12.8%, respectively, of the 462 patients with other neurologic diseases (P<0.001). Two-thirds of cases of MI were clinically silent and found at autopsy. Compared with other neurologic diseases, and after adjusting for age, gender, and heart weight, the odds ratios (95% confidence intervals) of the presence of coronary plaques, coronary stenosis, and MI in stroke patients were 3.81 (2.66 to 5.46), 2.80 (1.85 to 4.25), and 2.34 (1.58 to 3.46), respectively. The frequency of coronary atherosclerosis and MI was similar between stroke subtypes. The prevalence of coronary plaques, coronary stenosis, and MI was 79.0%, 42.9%, and 46.0%, respectively, in the presence of plaques in any segment of the extracranial and intracranial brain arteries, and 50.8%, 17.9%, and 23.9%, respectively, in the absence of plaques (adjusted P<0.01). Coronary atherosclerosis was also related to the severity of atherosclerosis in any segment of the cerebral arteries (adjusted probability value for linear trend <.005).

Conclusions--Coronary atherosclerosis and MI are highly prevalent in patients who died from a stroke regardless of the etiology. They are more frequent when atherosclerosis is present in the carotid and cerebral arteries. They are also common in stroke patients with no evidence of carotid or cerebral atherosclerosis.

Key words: atherosclerosis • cerebral infarction • coronary arteries • myocardial infarction

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