Published Online
on March 1, 2007

A more recent version of this article appeared on April 1, 2007

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Submitted on November 14, 2006
Accepted on November 22, 2006

Pravastatin Decreases Wall Shear Stress and Blood Velocity in the Internal Carotid Artery Without Affecting Flow Volume. Results From the PROSPER MRI Study

Frieke M.A. Box MS^*; Jeroen van der Grond PhD; Anton J.M. de Craen PhD; Inge H. Palm-Meinders MD; Rob J. van der Geest MS; J. Wouter Jukema MD, PhD; Johan H.C. Reiber PhD; Mark A. van Buchem MD, PhD; Gerard J. Blauw MD, PhD; for the PROSPER Study Group

From the Division of Image Processing (F.M.A.B., R.J.v.d.G., J.H.C.R.) of the Department of Radiology (J.v.d.G., I.H.P.M. M.A.v.B.) and the Departments of Gerontology & Geriatrics (A.J.M.d.C., G.J.B.) and Cardiology (J.W.J.) Leiden University Medical Center, Leiden, the Netherlands.

^* To whom correspondence should be addressed. E-mail: F.M.A.Box{at}lumc.nl.

Background and Purpose--Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated.

Methods--In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging.

Results--WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased faster in the pravastatin group (P<0.04, P<0.02). Blood volume flow did not differ between the groups.

Conclusions--In elderly subjects, the WSS and blood velocity of the internal carotid artery declines significantly over time and this decline is more pronounced in subjects treated with 40 mg pravastatin compared with the placebo group.

Key words: blood flow • blood flow velocity • computer-assisted • image processing • magnetic resonance imaging • statins

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