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(Stroke. 1970;1:194.)
© 1970 American Heart Association, Inc.

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Effects of Breathing O₂ or O₂ + CO₂ and of the Injection of Neurohumors on the PO₂ of Cat Cerebral Cortex

WILLIAM J. WHALEN PH.D.¹; ROGER GANFIELD PH.D.¹; PANKAJAM NAIR PH.D.¹

¹ St. Vincent Charity Hospital, Cleveland, Ohio, 44115

Tissue PO₂ was measured in the outer 1.7 mm of the brain of the lightly anesthetized cat by means of a micro O₂ electrode introduced through a small hole in the skull. There was considerable variation from one location to another and from animal to animal. The interindividual variation was not related to the level of the arterial pressure or to rectal temperature. Individual values for the PO₂ in 569 locations in the 11 cats ranged from 0 to 90 mm Hg with a mean of 25. There was a significant downward trend in PO₂ from the surface layers inward. When the electrode was left in one location, the PO₂ usually fluctuated, though not often rhythmically as seen in skeletal muscle. Breathing pure O₂ (N=41) or 95% O₂ – 5% CO₂ (N = 33) caused an equal (50%) increase in PO₂. The intravenous injection of epinephrine or norepinephrine caused a primary rise in PO₂ usually with a secondary decrease. Acetylcholine caused a primary decrease and usually a secondary increase.

Key Words: tissue PO₂ • epinephrine • norepinephrine • hypercapnia • acetylcholine • hypocapnia • brain PO₂

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