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(Stroke. 1970;1:314.)
© 1970 American Heart Association, Inc.

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Effects of Inhalation of Oxygen on Blood Flow and Microvasculature of Ischemic and Nonischemic Cerebral Cortex

FRANCO REGLI M.D.¹; TAKENORI YAMAGUCHI M.D.¹; ARTHUR G. WALTZ M.D.¹

¹ Cerebrovascular Clinical Research Center and the Department of Neurology, Mayo Clinic and Mayo Foundation, and Mayo Graduate School of Medicine (University of Minnesota), Rochester, Minnesota

The right middle cerebral artery was occluded in cats, and Pa_oo2 was increased by increasing the amount of oxygen inhaled by the animals at atmospheric pressure. Cortical blood flow (CBF) was measured with Krypton-85, and observations and photographs of the superficial cortical microvasculature were made bilaterally. In two of five animals, increasing the Pa_oo2 caused constriction of surface arterioles of the nonischemic hemispheres, with an associated decrease of CBF; in the three other animals, there were no circulatory responses to the increased Pa_oo2. In seven animals, increasing the Pa_oo2 had no apparent effect on CBF or arteriolar caliber of the ischemic cerebral hemispheres. In four animals, at Pa_oo2 greater than 400 torr, reactivity to increases of Pa_COCO2 was preserved in nonischemic cortex but impaired in ischemic cortex. Reddening of venous blood of the microvasculature of ischemic cerebral cortex occurred when Pa_oo2 was increased, indicating that more oxygen was made available to the ischemic cerebral tissue. However, no beneficial effects could be demonstrated on the changes in the microvasculature produced by ischemia.

Key Words: cerebral infarction • microcirculation of brain • oxygen therapy • krypton • hyperoxia

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