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(Stroke. 1970;1:325.)
© 1970 American Heart Association, Inc.


The Effect of Isordil and Cyclospasmol on Vascular Spasm Induced in the Basilar Artery of the Cat

M. S. MAHALEY JR. M.D., PH.D.1 JOHN KAPP M.D., PH.D.1

1 Division of Neurosurgery and Anatomy, Duke University Medical Center, Durham, North Carolina, 27706

Vasospasm of the basilar artery of the cat was induced by subarachnoid bleeding and was observed by a transoral approach to the vessel. Intravenous Isordil (2 to 4 mg/kg) given following vasospasm produced vasodilatation with minimal arterial hypotension. Cyclospasmol, administered intravenously after vasospasm or orally prior to vasospasm, was ineffective in relieving or preventing basilar artery spasm.


Key Words: brain spasmolytic drugs