Stroke, Vol 12, 301-306, Copyright © 1981 by American Heart Association
F Iannotti, A Crockard, G Ladds and L Symon
Sixty-five male gerbils, divided into 3 groups, were used in this study, in
which focal brain specific gravity, taken as a measure of edema, was
compared to the corresponding focal cerebral blood flow using the hydrogen
washout technique. Extracranial unilateral or bilateral carotid ligation
was performed and one hour later the animal was sacrificed. When focal
blood flow was less than 20 ml/100 g/min, edema developed and increased
with progressive ischemia, reaching maximal values at 5-7 ml/100 g/min. In
the zero flow situation there was no edema. Pretreatment of the other 2
groups with indomethacin or dexamethasone, did not prevent edema formation
at flows of 20-12 ml/200 g/min, but considerably reduced the edema
previously noted at low flows (5-7 ml/100 g/min). The drugs did not affect
the decreased flow in the ischemic area. We conclude that prostaglandins,
released by membrane disruption, are involved in the development of
ischemic edema.
ARTICLES
Are prostaglandins involved in experimental ischemic edema in gerbils?
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