This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Capraro, J. A. Articles by Little, J. R. Search for Related Content PubMed PubMed Citation Articles by Capraro, J. A. Articles by Little, J. R.

Stroke, Vol 15, 486-491, Copyright © 1984 by American Heart Association

ARTICLES

Treatment of acute focal cerebral ischemia with propranolol

JA Capraro, DP Reedy, JP Latchaw, RM Slugg, NT Stowe, RP Lesser and JR Little

Propranolol's potential as a protective agent against tissue injury has been noted in experimental myocardial, renal and early acute focal cerebral ischemia. The purpose of the present investigation was to study further the effects of racemic (d,l) propranolol on blood-brain barrier permeability, morphological changes, cortical electrical activity, and regional cerebral blood flow (rCBF) in experimental focal cerebral ischemia. Thirty adult cats, anesthetized with nitrous oxide, underwent 6 hours of right middle cerebral artery (MCA) occlusion. Fifteen cats were untreated. Fifteen cats were given a continuous infusion of racemic propranolol (1 mg/kg/hr) for 7 hours beginning 1 hour before MCA occlusion and a 4 mg/kg bolus immediately before occlusion, both directly into the right carotid artery. Right Sylvian rCBF did not significantly differ in the treated and untreated groups. Carbon filling defects and vital dye (i.e., Evans blue and fluorescein) extravasation were less severe in the propranolol treated animals. Light microscopic findings demonstrated no difference in infarct size between the two groups. The findings suggest that at doses given, racemic propranolol does not exert a protective effect upon cerebral tissue subjected to 6 hours of incomplete ischemia.

This article has been cited by other articles:

				R.-Q. Han, Y.-B. Ouyang, L. Xu, R. Agrawal, A. J. Patterson, and R. G. Giffard Postischemic Brain Injury Is Attenuated in Mice Lacking the {beta}2-Adrenergic Receptor Anesth. Analg., January 1, 2009; 108(1): 280 - 287. [Abstract] [Full Text] [PDF]

				T. Goyagi, T. Kimura, T. Nishikawa, Y. Tobe, and Y. Masaki {beta}-Adrenoreceptor Antagonists Attenuate Brain Injury After Transient Focal Ischemia in Rats. Anesth. Analg., September 1, 2006; 103(3): 658 - 663. [Abstract] [Full Text] [PDF]

				C. Tegeler and D. Sherman Analytic Review: Ischemic Cerebrovascular Disease: Diagnosis and Management J Intensive Care Med, July 1, 1986; 1(4): 184 - 196. [Abstract] [PDF]