Stroke, Vol 15, 891-895, Copyright © 1984 by American Heart Association
KK Bhakoo, HA Crockard, PC Lascelles and SF Avery
Regional brain tissue prostaglandin (PG) levels have been measured during
ischaemia produced by bilateral carotid occlusion for 1 hour and following
restoration of flow. In the normal gerbil, the frontal cortical levels of
PGF2 alpha were: 6.7 +/- 1.3 pg/mg and for PGE2: 6.4 +/- 1.1 pg/mg of brain
tissue protein. Following 1 hour of ischaemia PGF2 alpha rose to 50.4 +/-
8.3 pg/mg whilst there was only a slight rise in PGE2 (10.7 +/- 1.6 pg/mg).
Post ischaemic values for parietal and occipital areas were somewhat
higher, but showed the same trend. Within 15 minutes of the restoration of
flow there was a massive increase in PGF2 alpha levels which reached a peak
at 2 hours (300 pg/mg) and then subsided to control values. PGE2 levels did
not change for the first 30 minutes of recirculation, but then rose for the
rest of the period of observation. The pattern of cytotoxic oedema
resembled PGF2 alpha closely while the Evans blue staining (vasogenic
oedema) was similar in time to the PGE2 pattern.
ARTICLES
Prostaglandin synthesis and oedema formation during reperfusion following experimental brain ischaemia in the gerbil
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